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Related Experiment Videos

Atenolol-associated cholestasis.

M S Schwartz1, M S Frank, A Yanoff

  • 1Department of Medicine, Albert Einstein College of Medicine, Bronx, New York.

The American Journal of Gastroenterology
|September 1, 1989
PubMed
Summary
This summary is machine-generated.

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Atenolol, a beta-blocker for hypertension, can rarely cause cholestatic hepatitis. Symptoms resolved after stopping the medication, highlighting a potential adverse effect for clinicians to monitor.

Area of Science:

  • Cardiology
  • Hepatology
  • Pharmacology

Background:

  • Atenolol is a widely prescribed beta-1 selective beta-adrenergic receptor antagonist.
  • It is commonly used for managing hypertension and angina pectoris.

Observation:

  • A case of cholestatic hepatitis developed in a patient shortly after initiating atenolol therapy.
  • The patient experienced resolution of hepatic symptoms and normalization of liver function tests upon atenolol withdrawal.

Findings:

  • This case represents a potential, previously unreported association between atenolol and drug-induced liver injury (DILI).
  • Literature review revealed no prior documented instances of atenolol-induced hepatic injury.

Implications:

Related Experiment Videos

  • Clinicians should consider atenolol as a potential cause of cholestatic hepatitis, even if rare.
  • Awareness of this adverse effect is crucial due to the widespread use of atenolol.