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Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

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Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
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Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

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Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
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Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

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Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
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Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

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Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
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Imbalances in Cardiac Output01:26

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The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
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Related Experiment Video

Updated: Mar 13, 2026

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo
05:14

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

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Acromegaly with Dilated Cardiomyopathy.

Ramesh R Dargad1, Jai D Parekh2, Rohit R Dargad3

  • 1Consulting Physician and Cardiologist, Stress Test Clinic, Mumbai, Maharashtra.

The Journal of the Association of Physicians of India
|October 15, 2016
PubMed
Summary

Acromegaly, a rare growth hormone excess disorder, can cause dilated cardiomyopathy. This case highlights a rare instance in an Indian female, emphasizing the need for timely diagnosis and treatment of growth hormone-secreting pituitary tumors.

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Area of Science:

  • Endocrinology
  • Cardiology
  • Oncology

Background:

  • Acromegaly results from excessive growth hormone (GH) secretion, often due to a pituitary tumor.
  • Cardiovascular complications, including dilated cardiomyopathy, are known but rare in acromegaly.
  • Dilated cardiomyopathy in acromegaly is associated with significant mortality.

Observation:

  • A 41-year-old Indian female presented with heart failure symptoms after a 6-year undiagnosed period of acromegaly.
  • Her heart failure was attributed to dilated cardiomyopathy caused by prolonged GH exposure.
  • A GH-secreting pituitary macroadenoma was identified as the underlying cause.

Findings:

  • The patient exhibited symptoms consistent with dilated cardiomyopathy and systolic/diastolic dysfunction.
  • The cardiac condition was directly linked to the excess growth hormone from the pituitary tumor.
  • Surgical resection of the pituitary macroadenoma was performed.

Implications:

  • This case underscores the critical link between acromegaly and rare cardiac manifestations like dilated cardiomyopathy.
  • It highlights the importance of early diagnosis and management of growth hormone excess to prevent severe cardiovascular outcomes.
  • The report contributes to the limited literature on acromegaly-induced dilated cardiomyopathy in Indian females.