Related Experiment Video
Updated: Mar 13, 2026
11:25
3D Multicolor DNA FISH Tool to Study Nuclear Architecture in Human Primary Cells
Published on: January 25, 2020
11.0K
Organization and function of the 3D genome.
Boyan Bonev1, Giacomo Cavalli1
1Institute of Human Genetics, UPR1142 National Centre for Scientific Research (CNRS); and University of Montpellier, 141 Rue de la Cardonille, 34396 Montpellier Cedex 5, France.
Nature Reviews. Genetics
|October 15, 2016
Summary
Chromatin organization in the nucleus is crucial for gene regulation and cell fate. Recent advances in quantitative biology and genomics are revealing mechanisms that establish, reset, and maintain this 3D structure.
Area of Science:
- Cell Biology
- Genomics
- Molecular Biology
Background:
- Chromatin's 3D organization is key to gene regulation, cell fate, and evolution.
- Mechanisms governing chromatin structure establishment, resetting, and maintenance remain poorly understood.
Purpose of the Study:
- To review recent technological advancements in understanding chromatin architecture.
- To explain how new insights address biological questions in development and disease.
Main Methods:
- Quantitative biology approaches
- Genomics techniques
- Cell and molecular biology methods
Main Results:
- Technological progress has yielded significant insights into chromatin architecture.
- New concepts link chromatin structure to development and disease.
Conclusions:
- Continued exploration of chromatin organization is vital for advancing cell biology.
- Understanding these mechanisms has broad implications for development and disease research.
Related Concept Videos
01:19The Nucleosome
4.6K
Human DNA is almost two meters long. However, it is compressed inside a tiny nucleus measuring only a few microns in diameter. To make this degree of compaction possible, DNA is organized into several sequential levels so that it can fit into such a tiny space. The most compact form of DNA is a chromosome that can be seen under a microscope in a dividing cell.
In a chromosome, DNA is wound twice around a protein complex called a histone octamer core, which consists of 8 histone proteins. This...
In a chromosome, DNA is wound twice around a protein complex called a histone octamer core, which consists of 8 histone proteins. This...
4.6K
02:33The Nucleosome
19.6K
DNA in a human cell is almost 2m long and it is packed inside a tiny nucleus that is only a few microns in diameter. The level of compaction of DNA inside the nucleus is astonishing. It is organized into several sequentially higher levels of compaction to fit into such a tiny space. The most compact form of DNA is a chromosome that can be seen under a microscope in a dividing cell.
DNA is wound twice around a protein complex called histone core, that consist of 8 histone proteins. This complex...
DNA is wound twice around a protein complex called histone core, that consist of 8 histone proteins. This complex...
19.6K
02:33The Nucleosome
5.5K
5.5K
01:32Chromatin Packaging
20.1K
Each human somatic cell contains 6 billion base pairs of DNA. Each base pair is 0.34 nm long, meaning each diploid cell contains a staggering 2 meters of DNA. This long DNA strand is packed inside a nucleus measuring only 10-20 microns in diameter with the help of specialized DNA-binding proteins called histones. Together they form a compact DNA-protein complex called chromatin. The chromatin is further compacted into higher-order structures. The highest level of compaction is achieved during...
20.1K
02:21Chromatin Packaging
22.8K
Each human somatic cell contains 6 billion base-pairs of DNA. Each base-pair is 0.34 nm long, which means that each diploid cell contains a staggering 2 meters of DNA. How is such a long DNA strand packed inside a nucleus measuring only 10 - 20 microns in diameter?
The chromatin
In combination with specialized DNA binding protein called Histones, the DNA double helix forms a compact DNA: protein complex called chromatin. The chromatin itself is further compacted into higher-order...
The chromatin
In combination with specialized DNA binding protein called Histones, the DNA double helix forms a compact DNA: protein complex called chromatin. The chromatin itself is further compacted into higher-order...
22.8K
02:21Chromatin Packaging
10.1K
10.1K