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CircRNAs in hematopoiesis and hematological malignancies
A Bonizzato1, E Gaffo2, G Te Kronnie1
1Department of Women's and Children's Health, University of Padova, Padova, Italy.
Blood Cancer Journal
|October 15, 2016
Summary
Circular RNAs (circRNAs) are stable RNA molecules found in blood cells. This review explores their role in normal and cancerous hematopoiesis, highlighting their regulatory functions and potential as biomarkers.
Area of Science:
- Molecular Biology
- Hematology
- Genomics
Background:
- Cellular states in hematopoiesis are regulated by master regulators and RNA species.
- Circular RNAs (circRNAs) are stable RNA molecules with unique properties.
- circRNAs are expressed in various tissues, including the hematopoietic system.
Purpose of the Study:
- To provide a comprehensive overview of circRNAs in hematopoiesis.
- To discuss circRNA biogenesis and its relevance to hematopoiesis.
- To examine the role of circRNAs in normal and malignant hematopoiesis.
Main Methods:
- Literature review of circRNA research in hematopoiesis.
- Analysis of RNA-seq data identifying circRNAs.
- Examination of circRNA expression in hematopoietic cells and malignancies.
Main Results:
- Thousands of circRNAs with tissue- and developmental stage-specific expression have been identified.
- circRNAs are abundantly expressed in the hematopoietic compartment.
- Pathogenic circRNAs derived from leukemia fusion genes have been identified.
Conclusions:
- circRNAs play significant roles in regulating gene expression and cellular processes in hematopoiesis.
- circRNA expression patterns differ in normal and malignant hematopoiesis, suggesting potential as biomarkers.
- Further research is warranted to fully elucidate the function and therapeutic potential of circRNAs in hematopoiesis.
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