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Technical Considerations for Red Marking Ink Use When Interpreting Specimen Radiographs: Case Report.

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Ink precipitates from tissue marking dye can mimic microcalcifications on breast cancer imaging. This artifact can lead to misinterpretation of lumpectomy margins, highlighting the need for careful evaluation of imaging findings.

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Area of Science:

  • Radiology
  • Pathology
  • Medical Imaging

Background:

  • Artifacts are common in medical imaging and can affect diagnostic accuracy.
  • Accurate assessment of surgical margins is crucial for effective breast cancer treatment.

Observation:

  • Three patients with breast cancer presented with densities resembling microcalcifications at lumpectomy resection margins.
  • Microscopic examination revealed negative margins, indicating the densities were not malignant.

Findings:

  • The observed densities were identified as pseudocalcifications, specifically ink precipitates from a common tissue marking dye.
  • This artifact was successfully reproduced using a chicken breast phantom, confirming its origin.

Implications:

  • Recognizing this ink artifact is essential to prevent misinterpretation of breast cancer resection margins.
  • This finding can improve the accuracy of post-lumpectomy margin assessment in breast cancer imaging.