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Legacy of MESA.
Jean L Olson1, Diane E Bild2, Richard A Kronmal3
1Division of Cardiovascular Sciences, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Global Heart
|October 16, 2016
Summary
The Multi-Ethnic Study of Atherosclerosis (MESA) tracks subclinical cardiovascular disease in over 6,000 adults. This long-term study uses advanced imaging and technology to understand disease progression and inform future cardiovascular research.
Area of Science:
- Cardiovascular epidemiology
- Public health research
- Biomedical imaging
Background:
- The Multi-Ethnic Study of Atherosclerosis (MESA) was established to investigate subclinical cardiovascular disease.
- It aimed to understand disease progression in a diverse population using advanced imaging.
Purpose of the Study:
- To address key questions regarding subclinical cardiovascular disease and its clinical manifestations.
- To create a population laboratory for ongoing and future cardiovascular research.
- To leverage emerging technologies for enhanced disease evaluation.
Main Methods:
- Recruited over 6,000 adults aged 45-84 from diverse racial/ethnic groups (2000-2002).
- Collected extensive cohort data through 5 exams (until 2011) and phone follow-ups.
- Incorporated ancillary studies and novel technologies in subsequent exams.
Main Results:
- Over 1,000 MESA papers have been published, contributing significantly to cardiovascular science.
- The study has provided extensive data on cardiovascular disease progression in a diverse population.
Conclusions:
- MESA has successfully generated a rich dataset for cardiovascular research.
- Future exams will incorporate novel technologies to address emerging research questions.
- The study continues to foster collaborations to advance cardiovascular science.
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