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Published on: July 21, 2018
Interrogating Metabolism in Brain Cancer.
Travis C Salzillo1, Jingzhe Hu2, Linda Nguyen3
1Department of Cancer Systems Imaging, MD Anderson Cancer Center, The University of Texas, Houston, TX, USA; The University of Texas Health Science Center at Houston, Houston, TX, USA.
This review covers brain cancer metabolism interrogation techniques, from proton magnetic resonance spectroscopy to advanced hyperpolarized metabolic imaging. These methods promise improved diagnosis and treatment assessment, potentially revolutionizing brain tumor understanding.
Area of Science:
- Neuro-oncology
- Metabolic Imaging
- Cancer Research
Background:
- Brain cancer metabolism is complex and crucial for tumorigenesis.
- Existing techniques for studying brain cancer metabolism have limitations.
- Emerging imaging modalities offer new insights into tumor biology.
Purpose of the Study:
- To review current and novel techniques for interrogating brain cancer metabolism.
- To highlight the potential of in vivo metabolomics and metabolic imaging in clinical practice.
- To discuss the integration of metabolic data with genomics and proteomics.
Main Methods:
- Proton magnetic resonance spectroscopy (MRS)
- Hyperpolarized metabolic imaging
- Chemical exchange saturation transfer (CEST) imaging
- Inflammation imaging techniques
Main Results:
- Proton MRS is a well-established technique.
- Hyperpolarized imaging and CEST show promise for metabolic assessment.
- Clinical trials are underway to validate these emerging techniques.
- Integration with genomics and proteomics is key for comprehensive understanding.
Conclusions:
- In vivo metabolomics and metabolic imaging represent the next frontier in brain cancer.
- These techniques are vital for accurate diagnosis and therapeutic efficacy assessment.
- Combining metabolic data with multi-omics approaches will advance brain tumor research.
