[The effect of forskolin on sperm motility. In vitro experiments with bull sperm]

We have investigated the effect of Forskolin, a substance that stimulates c-AMP, on the motility of freshly thawed bull-sperm. Forskolin was added in amounts of 25.78 and 2.57 micrograms. In control samples we employed saline. An amount of 25.78 micrograms Forskolin increased significantly the procentage of motile spermatozoa compared with 2.57 micrograms Forskolin or saline. The mean velocity of the motile sperm is decreased slightly, but constantly, over a period of 130 minutes by Forskolin (25.78 micrograms), but not by 2.57 micrograms Forskolin or saline. With respect to progressive motile sperm and their mean velocity, there were no significant differences detectable. The usefulness of Forskolin in reproductive medicine needs further evaluation.