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Updated: Mar 13, 2026

Whole-body Mass Spectrometry Imaging by Infrared Matrix-assisted Laser Desorption Electrospray Ionization IR-MALDESI
Published on: March 24, 2016
MALDI mass spectrometry imaging in rheumatic diseases
Beatriz Rocha1, Berta Cillero-Pastor2, Francisco J Blanco3
1Proteomics Unit-ProteoRed/ISCIII, Rheumatology Group, INIBIC - Hospital Universitario de A Coruña, SERGAS, A Coruña, Spain.
Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) visualizes biomolecules in tissues. This review highlights its use in rheumatology for understanding joint diseases and finding diagnostic biomarkers.
Area of Science:
- Biomedical imaging
- Analytical chemistry
- Mass spectrometry
Background:
- Mass spectrometry imaging (MSI) visualizes biomolecule distribution in tissues.
- MALDI-MSI offers sensitive, label-free imaging of peptides and proteins.
- It is increasingly used in biomarker discovery and tissue classification.
Purpose of the Study:
- To review MALDI-MSI applications in rheumatology.
- To summarize achievements in understanding rheumatic pathologies.
- To identify potential diagnostic and prognostic biomarkers for rheumatic diseases.
Main Methods:
- Review of studies utilizing MALDI-MSI in rheumatology.
- Analysis of joint tissues (synovial membrane, cartilage).
- Focus on protein and peptide biomarker imaging.
Main Results:
- MALDI-MSI enhances understanding of rheumatic pathologies.
- Identified potential biomarkers for diagnosis and prognosis.
- Demonstrated utility in analyzing joint tissues.
Conclusions:
- MALDI-MSI is a valuable tool in rheumatology research.
- It aids in biomarker discovery for rheumatic diseases.
- Further applications in clinical diagnostics are promising.
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