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Associations of Maternal and Paternal Blood Pressure Patterns and Hypertensive Disorders during Pregnancy with

Kozeta Miliku1, Nienke E Bergen2, Hanneke Bakker1

  • 1The Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, The Netherlands Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands Department of Pediatrics, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.

Journal of the American Heart Association
|October 16, 2016
PubMed

Insights

Maternal and paternal blood pressure influence childhood blood pressure. Early pregnancy maternal blood pressure showed the strongest association with offspring

Area of Science:

  • Cardiovascular health
  • Pediatric health
  • Pregnancy research

Background:

  • Hypertensive disorders during pregnancy may increase offspring cardiovascular risk.
  • Understanding parental blood pressure effects on child blood pressure is crucial.
  • Investigating critical pregnancy periods for these effects is important.

Purpose of the Study:

  • To examine maternal blood pressure throughout pregnancy and hypertensive disorders in pregnancy on childhood blood pressure.
  • To compare maternal and paternal blood pressure effects on offspring.
  • To identify critical pregnancy periods and the role of birth outcomes and childhood BMI.

Main Methods:

  • Prospective cohort study of 5310 mother-father-child trios.
  • Maternal blood pressure measured each trimester; paternal blood pressure once.
  • Childhood blood pressure measured at median age 6.0 years.

Main Results:

  • Both maternal and paternal blood pressure positively associated with childhood blood pressure (P<0.05).
  • Early, mid-, and late-pregnancy maternal blood pressure independently associated with childhood BP; early pregnancy had strongest effect.
  • Children of mothers with hypertensive disorders had higher diastolic BP (0.13 SDS).

Conclusions:

  • Maternal and paternal blood pressure impact childhood blood pressure.
  • Early pregnancy maternal blood pressure has the most significant effect.
  • Associations were independent of birth outcomes and childhood BMI.
Abstract

Keywords:
blood pressuregestational hypertensionpediatricspreeclampsiapregnancy

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