Related Experiment Video

Updated: Mar 13, 2026

A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation
16:40

A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation

Published on: February 28, 2012

26.9K

Kidney function and appropriateness of device therapies in adults with implantable cardioverter defibrillators

Nisha Bansal1, Adam Szpiro2, Frederick Masoudi3

  • 1Division of Nephrology, Kidney Research Institute, University of Washington, Seattle, Washington, USA.

Heart (British Cardiac Society)
|October 16, 2016
PubMed

Insights

Chronic kidney disease (CKD) did not increase the risk of device therapies in patients receiving primary prevention implantable cardioverter defibrillators (ICDs). These findings suggest CKD should not prevent eligible patients from receiving ICDs.

Area of Science:

  • Cardiology
  • Nephrology
  • Medical Devices

Background:

  • Patients with chronic kidney disease (CKD) face a higher risk of sudden cardiac death.
  • Implantable cardioverter defibrillators (ICDs) are crucial for preventing sudden cardiac death.
  • Concerns exist regarding increased complication risks, including device therapies, in CKD patients receiving ICDs.

Purpose of the Study:

  • To evaluate the association between CKD and the risk of device-delivered shocks or antitachycardia pacing (ATP) therapies in primary prevention ICD recipients.
  • To determine if CKD influences the timing, burden, or appropriateness of ICD therapies.

Main Methods:

  • A cohort study of 2161 participants receiving primary prevention ICDs was analyzed.
  • CKD was defined as an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m².
  • Outcomes included all delivered shocks/ATPs, their appropriateness, and timing over 3 years, with adjustments for covariates.

Main Results:

  • Among 2161 participants, 49.3% had CKD.
  • CKD was not associated with the time to first shock/ATP therapy (aHR 0.87; 95% CI 0.73-1.05).
  • No significant association was found between CKD and the overall burden or appropriateness of device therapies.

Conclusions:

  • Mild-to-moderate CKD is not associated with increased risk of timing, burden, or appropriateness of ICD therapies.
  • Concerns about inappropriate ICD therapies should not deter ICD implantation in eligible CKD patients.
  • Further research may explore specific CKD subpopulations and advanced device therapies.
Abstract

More Related Videos

Implantation of the Syncardia Total Artificial Heart16:11

Implantation of the Syncardia Total Artificial Heart

Published on: July 18, 2014

36.2K
Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock07:39

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock

Published on: August 16, 2021

4.2K

Related Concept Videos

Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
574
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
497
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
702
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
445
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in...
315
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
646