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The associations between MDM4 gene polymorphisms and cancer risk
Ming-Jie Wang1, Yong-Jun Luo2, Zhi-Yong Shi3
1Department of Orthopedics, Affiliated Hospital of Nanjing Medical University, Changzhou Second People's Hospital, Changzhou 213003, China.
The MDM4 gene rs4245739 polymorphism is linked to overall cancer risk, particularly in Asian populations and nonsmokers. Other MDM4 gene variations showed no significant cancer risk association in this meta-analysis.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- The MDM4 gene plays a role in tumor suppression.
- Previous studies on MDM4 gene polymorphisms and cancer risk have yielded conflicting results.
- Understanding these associations is crucial for cancer etiology research.
Purpose of the Study:
- To conduct a meta-analysis evaluating the association between MDM4 gene polymorphisms and cancer risk.
- To clarify the contradictory findings in existing literature.
Main Methods:
- Systematic literature search of PubMed, Embase, and CNKI databases.
- Meta-analysis of 56 studies (18,910 cases, 51,609 controls).
- Evaluation of five MDM4 gene polymorphisms: rs4245739, rs1563828, rs11801299, rs10900598, and rs1380576.
Main Results:
- The rs4245739 polymorphism was significantly associated with overall cancer risk.
- Stratification revealed rs4245739 decreased cancer risk in Asian populations and nonsmokers.
- No significant association was found for rs1563828, rs11801299, rs10900598, or rs1380576 with overall cancer risk.
Conclusions:
- The MDM4 gene rs4245739 polymorphism may be important in cancer etiology.
- Further research is warranted to elucidate the specific mechanisms.
- This meta-analysis provides a comprehensive overview of MDM4 polymorphisms and cancer risk.
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