Related Experiment Video
Updated: Mar 13, 2026
08:42
A Reproducible Cartilage Impact Model to Generate Post-Traumatic Osteoarthritis in the Rabbit
Published on: November 21, 2023
2.0K
Osteochondritis dissecans patellae : Is there a genetic predisposition?
Peter J Livesley1, George F Milligan1,2
1Harlow Wood Orthopaedic Hospital, NG184QT, Mansfield, Nottinghamshire, England.
International Orthopaedics
|October 16, 2016
Summary
Osteochondritis Dissecans Patellae (OCD Patellae) may stem from inherited knee mechanics leading to recurrent patellar subluxation. This family study suggests a genetic link to the condition
Area of Science:
- Orthopedics
- Genetics
- Biomechanics
Background:
- The exact cause of Osteochondritis Dissecans Patellae (OCD Patellae) is not fully understood.
- Genetic and mechanical factors are suspected contributors.
Purpose of the Study:
- To investigate the aetiology of OCD Patellae in a familial context.
- To explore the role of inherited knee mechanics and patellar instability.
Main Methods:
- Clinical data collection from a family with multiple affected members across one generation.
- Analysis of clinical findings to support or refute hypotheses on aetiology.
Main Results:
- The study identified a family where all members of one generation presented with OCD Patellae.
- Clinical data indicated recurrent subluxation of the patella as the likely cause in this family.
Conclusions:
- An inherited abnormality in knee mechanics may predispose individuals to recurrent patellar subluxation, leading to OCD Patellae.
- This suggests a potential genetic component in the aetiology of OCD Patellae.
Related Concept Videos
01:16Bones of the Lower Limb: Femur and Patella
9.0K
The femur is the body's longest and strongest bone spanning the thigh region. Its head articulates with the acetabulum of the hip bone to form the hip joint. A minor indentation on the medial side of the femoral head, called the fovea capitis, serves as the site of attachment for the ligament of the head of the femur. This weak ligament spans the femur and acetabulum and supports the hip joint. The narrowed region below the head is the neck of the femur. The inclination angle between the...
9.0K
01:29Bone Disorders
5.9K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.9K