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24-gene predictor of response to postoperative irradiation

Michel Bolla1

  • 1Grenoble-Alpes University, Grenoble University Hospital, 38043 Grenoble, Cedex 9, France.

The Lancet. Oncology
|October 17, 2016
PubMed
Abstract

No abstract available in PubMed .

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
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