A brief glimpse at CTRP3 and CTRP9 in lipid metabolism and cardiovascular protection
Yang Yang1, Yue Li2, Zhiqiang Ma3
1Department of Cardiovascular Surgery, Xijing Hospital, The Fourth Military Medical University, 127 Changle West Road, Xi'an 710032, China; Department of Biomedical Engineering, The Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, China; Department of Thoracic and Cardiovascular Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing 210008, Jiangsu, China.
Abstract:
Adipose tissue is now known to express and secrete numerous adipokines that not only regulate lipid metabolism but also function in a wide array of physiological or pathological processes. C1q tumor necrosis factor-related protein 3 (CTRP3, also known as CORS26/cartducin) and CTRP9, novel members of the adipokine family, have intersecting functions in the regulation of lipid metabolism and contribute to cardiovascular protection. Here, we focus on the novel advances concerning the roles of CTRP3 and CTRP9 in these processes and review the general mechanisms. This review should serve as a basis for the design of future experimental studies and may implicate these adipokines as future therapeutic targets.
Related Concept Videos
Lipid Catabolism
Transducer Mechanism: Enzyme-Linked Receptors
Major types that are helpful drug targets include:
Pharmacogenomics: Identification of New Drug Targets
Global Regulatory Systems
Enzyme-linked Receptors
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
Cholesterol: Significance and Regulation
Considering cholesterol and...


