Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

2.1K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
2.1K
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

10.2K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
10.2K
Introduction to Innate and Adaptive Immunity01:21

Introduction to Innate and Adaptive Immunity

11.1K
The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
11.1K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

85.7K
Overview
85.7K
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

1.8K
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
1.8K
GPCRs Regulate Adenylyl Cylase Activity01:09

GPCRs Regulate Adenylyl Cylase Activity

8.0K
Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of...
8.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction to: Low reticulocyte count at infusion is a risk factor for high-grade cytokine release syndrome in chimeric antigen receptor T cell therapy.

International journal of hematology·2026
Same author

Impact of Acute Graft-Versus-Host Disease and Delayed Hematopoietic Recovery on the Incidence and Clinical Burden of Late Cytomegalovirus Reactivation and Disease after Letermovir Prophylaxis during the First 100 Days after Cord Blood Transplantation.

Transplantation and cellular therapy·2026
Same author

T-cell large granular lymphocyte leukaemia with pure red cell aplasia harbouring a somatic <i>STAT3</i> P715L mutation.

BMJ case reports·2026
Same author

Usefulness of pegfilgrastim for allogeneic peripheral blood stem cell collection from healthy donors.

Transfusion·2026
Same author

Prolonged Cytokine Release Syndrome is Associated with Hypofibrinogenemia after CD19-Directed CAR T-Cell Therapy in Adult Patients with Relapsed/Refractory Lymphoma.

Transplantation and cellular therapy·2026
Same author

A diagnostic pitfall in cold agglutinin disease: KMT2D-mutated CAD-associated lymphoproliferative disorder with a CLL-like immunophenotype.

Oxford medical case reports·2026

Related Experiment Video

Updated: Mar 13, 2026

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
09:52

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

Published on: August 8, 2014

18.2K

IgG4-Related Disease and Innate Immunity.

Tomohiro Watanabe1, Kouhei Yamashita2, Masatoshi Kudo3

  • 1Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, 377-2, Ohno-Higashi, Osaka-Sayama, Osaka, 589-8511, Japan. tmhrwtnb@kuhp.kyoto-u.ac.jp.

Current Topics in Microbiology and Immunology
|October 17, 2016
PubMed
Summary
This summary is machine-generated.

Immunoglobulin G4-related disease (IgG4-RD) involves innate immune cells promoting IgG4 production. Understanding this innate immune response may reveal new therapeutic targets for IgG4-RD.

More Related Videos

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies
09:08

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies

Published on: June 2, 2021

2.1K
In Vivo Two-Color 2-Photon Imaging of Genetically-Tagged Reporter Cells in the Skin
05:45

In Vivo Two-Color 2-Photon Imaging of Genetically-Tagged Reporter Cells in the Skin

Published on: July 11, 2019

8.0K

Related Experiment Videos

Last Updated: Mar 13, 2026

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
09:52

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

Published on: August 8, 2014

18.2K
Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies
09:08

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies

Published on: June 2, 2021

2.1K
In Vivo Two-Color 2-Photon Imaging of Genetically-Tagged Reporter Cells in the Skin
05:45

In Vivo Two-Color 2-Photon Imaging of Genetically-Tagged Reporter Cells in the Skin

Published on: July 11, 2019

8.0K

Area of Science:

  • Immunology
  • Rheumatology

Background:

  • Immunoglobulin G4-related disease (IgG4-RD) is a novel disorder characterized by elevated serum IgG4 and IgG4-positive plasma cell infiltration.
  • The precise immunological mechanisms underlying IgG4-RD pathogenesis are not fully understood.
  • Emerging evidence suggests a role for the innate immune system in IgG4-RD development.

Purpose of the Study:

  • To explore the involvement of the innate immune response in the pathogenesis of IgG4-RD.
  • To investigate how innate immune cells influence IgG4 production in patients with IgG4-RD.

Main Methods:

  • Analysis of peripheral blood innate immune cells (plasmacytoid dendritic cells, monocytes) from IgG4-RD patients.
  • Assessment of the impact of these innate immune cells on B cell IgG4 production.
  • Investigation of molecular patterns (microbe- and damage-associated) activating the innate immune response.

Main Results:

  • Innate immune cells from IgG4-RD patients promote IgG4 production by B cells.
  • Activation of innate immunity by molecular patterns stimulates type I interferon and B cell-activating factor production.
  • This activation cascade leads to increased IgG4 production by B cells.

Conclusions:

  • The innate immune response plays a significant role in IgG4-RD pathogenesis.
  • Innate immune cells and their signaling pathways are potential therapeutic targets for IgG4-RD.
  • Further research into the innate immune mechanisms of IgG4-RD could lead to novel treatment strategies.