Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

1.4K
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
1.4K
Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

1.1K
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
1.1K
Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

1.1K
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
1.1K
Gastroesophageal Reflux Disease I: Meaning and Pathophysiology01:29

Gastroesophageal Reflux Disease I: Meaning and Pathophysiology

2.0K
Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
2.0K
Esophagus01:24

Esophagus

4.3K
The esophagus, a muscular conduit linking the pharynx and stomach, measures roughly 10 inches (25.4 cm) and sits behind the trachea. It remains collapsed when not swallowing. The esophagus follows a predominantly straight path through the thoracic mediastinum and enters the abdominal cavity through a diaphragmatic opening known as the esophageal hiatus.
The movement of edibles from the pharynx into the esophagus is facilitated by the upper esophageal sphincter, which is formed primarily by the...
4.3K
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

1.1K
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Esophageal Clearance Assessed by High-Resolution Impedance Manometry in Achalasia: A Prospective Study With 1-Year Follow-up.

The American journal of gastroenterology·2026
Same author

Laryngopharyngeal Symptoms and Laryngopharyngeal Reflux Disease: Diagnostic Testing and Clinical Approach Based on the San Diego Consensus.

Neurogastroenterology and motility·2026
Same author

Artificial Intelligence Chatbots for Dysphagia Patient Education: A Multi-Center International Expert Evaluation.

Neurogastroenterology and motility·2026
Same author

Functional Esophageal Disorders.

Gastroenterology·2026
Same author

Impact of Early-Onset IBS on Schooling, Illness in Adulthood, and Career Prospects.

Neurogastroenterology and motility·2026
Same author

Neurogastroenterology and Motility: Toward New Horizons in 2026.

Neurogastroenterology and motility·2026
Same journal

Predictive analytics and risk stratification models in internal medicine: from risk scores to real-time machine learning.

Presse medicale (Paris, France : 1983)·2026
Same journal

Artificial Intelligence in skin disease therapeutics: from drug discovery to personalized treatment pathways.

Presse medicale (Paris, France : 1983)·2026
Same journal

AI in clinical diagnostics in dermatology: applications, validation, and real-world use cases.

Presse medicale (Paris, France : 1983)·2026
Same journal

Artificial Intelligence in medical research and publishing: progress, risks, and future perspectives.

Presse medicale (Paris, France : 1983)·2026
Same journal

Ethical, legal, and regulatory challenges in AI-based healthcare tools.

Presse medicale (Paris, France : 1983)·2026
Same journal

Decision-making for clinicians.

Presse medicale (Paris, France : 1983)·2026
See all related articles

Related Experiment Video

Updated: Mar 13, 2026

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
03:23

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

Published on: May 10, 2024

1.5K

[Eosinophilic esophagitis].

Frank Zerbib1

  • 1CHU de Bordeaux, hôpital du Haut-Lévêque, service d'hépato-gastroentérologie et oncologie digestive, avenue Magellan, 33600 Pessac, France.

Presse Medicale (Paris, France : 1983)
|October 18, 2016
PubMed
Summary
This summary is machine-generated.

Eosinophilic esophagitis, a condition causing swallowing difficulties, is diagnosed via endoscopy and biopsy. Treatment includes proton pump inhibitors, topical steroids, or dietary changes, with endoscopic dilation for strictures.

More Related Videos

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation
10:15

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation

Published on: March 22, 2017

7.4K
Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

896

Related Experiment Videos

Last Updated: Mar 13, 2026

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
03:23

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

Published on: May 10, 2024

1.5K
Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation
10:15

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation

Published on: March 22, 2017

7.4K
Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

896

Area of Science:

  • Gastroenterology
  • Immunology
  • Allergy

Background:

  • Eosinophilic esophagitis (EoE) is a significant cause of dysphagia and esophageal food impaction, particularly in young adults.
  • Diagnosis relies on endoscopic findings and esophageal biopsy confirmation.
  • Proton pump inhibitors (PPIs) are the primary treatment, with variable response rates.

Purpose of the Study:

  • To outline diagnostic criteria and therapeutic strategies for eosinophilic esophagitis.
  • To discuss the efficacy of various treatment modalities, including pharmacotherapy and dietary interventions.
  • To provide guidance on managing complications such as esophageal strictures.

Main Methods:

  • Diagnostic confirmation through endoscopic visualization of esophageal mucosa and histological examination of biopsy samples.
  • Evaluation of treatment responses to proton pump inhibitors (PPIs) and topical steroids.
  • Assessment of dietary elimination and reintroduction protocols for allergen identification.
  • Consideration of endoscopic dilatations for esophageal strictures.

Main Results:

  • Approximately 50% of patients respond to proton pump inhibitor therapy.
  • Dietary allergen elimination achieves a 75% clinical and histological remission rate.
  • Topical steroids serve as a second-line treatment option.
  • Endoscopic dilatations are indicated for significant esophageal strictures.

Conclusions:

  • Eosinophilic esophagitis requires a multi-faceted approach combining pharmacotherapy, dietary management, and endoscopic interventions.
  • Accurate diagnosis and tailored treatment plans are crucial for managing symptoms and preventing complications.
  • Patient education on treatment modalities, especially dietary protocols, is essential for successful management.