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Interventional treatments for Hailey-Hailey disease.

Benjamin Farahnik1, Collin M Blattner2, Michael B Mortazie3

  • 1Department of Dermatology, University of Vermont, Burlington, Vermont.

Journal of the American Academy of Dermatology
|October 18, 2016
PubMed
Summary

Hailey-Hailey disease, a rare skin condition, presents challenges for extensive cases. This review summarizes evidence for various treatments beyond conventional therapies, aiding clinical decisions.

Keywords:
Hailey-Hailey diseasebotulinum toxin type Afamilial benign chronic pemphigusinterventional treatmentslaser ablationrecalcitrant Hailey-Hailey disease

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Area of Science:

  • Dermatology
  • Genetics

Background:

  • Hailey-Hailey disease (HHD), or familial benign chronic pemphigus, is a rare blistering skin disorder.
  • Characterized by recurrent erythematous plaques, HHD typically affects skin folds.

Purpose of the Study:

  • To review and summarize evidence for various treatment modalities for Hailey-Hailey disease.
  • To provide guidance on recommended treatments for extensive and recalcitrant HHD.

Main Methods:

  • Literature review of reported treatments for Hailey-Hailey disease.
  • Summary of evidence for therapies including laser ablation, photodynamic therapy, and others.

Main Results:

  • Several treatments like laser ablation, photodynamic therapy, and botulinum toxin type A show promise for extensive HHD.
  • Comparative trial data for these advanced treatments is currently lacking.

Conclusions:

  • A range of therapeutic options exist for recalcitrant Hailey-Hailey disease.
  • Further comparative studies are needed to establish definitive evidence-based treatment guidelines for HHD.