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Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery

Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery

Published on: May 2, 2019

Smart polymeric nanocarriers for small nucleic acid delivery.

Kanjiro Miyata¹

¹Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo.

Drug Discoveries & Therapeutics

|October 18, 2016

Summary

Nucleic acid therapeutics show promise but face delivery challenges. This review focuses on polymer carriers and responsive chemistry to improve systemic delivery and overcome biological barriers for these advanced medicines.

Area of Science:

Biomedical Engineering
Drug Delivery
Molecular Therapeutics

Background:

Nucleic acid therapeutics offer high target specificity for treating diseases.
Limited approved nucleic acid drugs are attributed to poor bioavailability.
Effective delivery carriers are essential for therapeutic success.

Purpose of the Study:

To review polymer-based delivery carriers for systemic administration of nucleic acids.
To highlight the role of biological environment-responsive chemistry in overcoming delivery barriers.
To discuss strategies for enhancing nucleic acid drug efficacy.

Main Methods:

Literature review of polymer-based nucleic acid delivery systems.
Analysis of biological barriers affecting systemic delivery.

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Last Updated: Mar 13, 2026

Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery

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Published on: May 2, 2019

Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry

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Published on: March 1, 2013

Assembly and Characterization of Polyelectrolyte Complex Micelles

Assembly and Characterization of Polyelectrolyte Complex Micelles

Published on: March 2, 2020

Exploration of responsive chemistry for targeted delivery.

Main Results:

Polymer carriers are a promising strategy for nucleic acid delivery.
Responsive chemistry can enhance carrier performance in biological environments.
Overcoming bioavailability issues is key to clinical translation.

Conclusions:

Polymer-based carriers are crucial for advancing nucleic acid therapeutics.
Responsive materials offer innovative solutions for targeted drug delivery.
Further development is needed to translate these findings into approved therapies.