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Pedunculated Nodules as a Variant of Dermatofibrosarcoma Protuberans
Min Jung Kim1, Min Seok Hur1, Byung Gon Choi1
1Department of Dermatology, Konkuk University School of Medicine, Seoul, Korea.
Annals of Dermatology
|October 18, 2016
Summary
Dermatofibrosarcoma protuberans (DFSP), a rare skin cancer, can present as multiple pedunculated nodules. This case highlights a rare variant of DFSP, successfully treated with wide excision and skin grafting.
Area of Science:
- Oncology
- Dermatopathology
Background:
- Dermatofibrosarcoma protuberans (DFSP) is a rare cutaneous sarcoma originating from dermal fibroblasts.
- It typically presents as a slow-growing, asymptomatic lesion, accounting for less than 5% of adult soft tissue sarcomas.
Observation:
- A 47-year-old male presented with multiple, well-circumscribed, firm, pedunculated nodules in the inguinal region over 7 months.
- This presentation is an unusual variant of DFSP, differing from typical solitary lesions.
Findings:
- Histopathologic examination revealed densely packed uniform spindle cells arranged in storiform and cartwheel patterns.
- Immunohistochemistry confirmed positivity for CD34, a key marker for DFSP.
Implications:
- Surgical management, including wide excision and skin grafting, proved effective in this case.
- Early diagnosis and appropriate treatment are crucial for managing this rare DFSP variant and preventing recurrence.
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