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Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization
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ApoptomiRs of Breast Cancer: Basics to Clinics

Shivani Sharma1, Praveen K Patnaik2, Stella Aronov2

  • 1Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology Delhi New Delhi, India.

Frontiers in Genetics
|October 18, 2016
PubMed

Insights

MicroRNAs (miRNAs) significantly regulate apoptosis, a key process in breast cancer development. Understanding these miRNA roles offers new therapeutic and prognostic strategies for breast cancer patients.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Deregulation of apoptosis, programmed cell death, is linked to breast cancer initiation, progression, and metastasis.
  • Targeting apoptosis induction is a key strategy in breast cancer therapy.
  • Identifying regulators of apoptosis is crucial for clinical applications.

Approach:

  • This review integrates current data on microRNA (miRNA) involvement in breast cancer apoptosis.
  • It explores the complex interplay between miRNAs, apoptotic factors, and p53.
  • Focuses on the clinical implications of miRNAs in breast cancer prognosis and treatment.

Key Points:

  • MicroRNAs play a critical role in controlling apoptosis.
  • The balance between pro- and anti-apoptotic factors is tightly regulated by miRNAs.
  • miRNAs interact with p53, a central regulator of apoptosis.
  • Dysregulation of miRNAs contributes to breast cancer pathogenesis.

Conclusions:

  • MicroRNAs are vital regulators of apoptosis in breast cancer.
  • miRNAs hold significant potential for improving breast cancer prognosis.
  • Targeting miRNA pathways may offer novel therapeutic avenues for breast cancer treatment.
Keywords:
apoptomiRapoptosisbiomarkerbreast cancermicroRNA

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