Related Experiment Video
Updated: Mar 13, 2026

Evaluation of Protein–Protein Interactions using an On-Membrane Digestion Technique
Published on: July 19, 2019
Role of Calpain in Pathogenesis of Human Disease Processes
Brittany A Potz1, M Ruhul Abid1, Frank W Sellke1
1Cardiothoracic Surgery Research Division, Warren Alpert Medical School of Brown University, Providence, RI, USA.
Abstract:
Calpains are a 15-member class of calcium activated nonlysosomal neutral proteases which are involved in a broad range of cellular function. Calpains are usually localized to the cytosol and within mitochondria. Calpastatin is an endogenous protein that specifically binds to and inhibits calpain. Overactivation of calpain has been implicated in a number of disease processes of the brain, eyes, heart, lungs, pancreas, kidneys, vascular system and skeletal muscle. Therefore, calpain may serve as a potential therapeutic target for a wide variety of disease processes. This review briefly outlines the current literature regarding the involvement of calpain overactivation in the pathogenesis of almost every organ in the body.
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