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Updated: Mar 13, 2026

A Microfluidic-based Hydrodynamic Trap for Single Particles

A Microfluidic-based Hydrodynamic Trap for Single Particles

Published on: January 21, 2011

A fluidic circuit based, high-efficiency and large-scale single cell trap.

Lu Mi¹, Liang Huang¹, Junxiang Li²

¹State Key Laboratory of Precision Measurement Technology and Instrument, Department of Precision Instrument, Tsinghua University, Beijing, China. wwh@tsinghua.edu.cn.

|October 18, 2016

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This study introduces a novel fluidic device for deterministic single cell trapping. Inspired by electric circuits, it enables efficient, flexible, and large-scale cell patterning for biological analysis.

Area of Science:

Biotechnology
Microfluidics
Cell Biology

Background:

Single cell manipulation and analysis are crucial in biological research.
Existing methods for cell trapping can lack efficiency and flexibility.

Purpose of the Study:

To present a novel single cell trap design and device.
To demonstrate deterministic single cell trapping with high efficiency and flexibility.

Main Methods:

Development of a fluidic device with a matrix of cell trap units.
Inspiration from equivalent resistive electric circuits for device design.
Application of the least flow resistance path principle for cell trapping.

Main Results:

Achieved deterministic single cell trapping.

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A Microfluidic-based Hydrodynamic Trap for Single Particles

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Demonstrated high trapping efficiency.

Showcased flexibility for large-scale cell patterning.

Conclusions:

The novel fluidic device offers a significant advancement in single cell manipulation.
The design enables precise and efficient large-scale cell patterning for various biological applications.