Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The return of elastomer valves.

W J Kolff1, L S Yu

  • 1Department of Surgery, University of Utah, Salt Lake City 84112.

The Annals of Thoracic Surgery
|September 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[The clinical characteristics and vestibular aqueduct morphology of Meniere's disease with or without migraine].

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery·2026
Same author

[Psychological changes in tinnitus patients at different disease stages and related factors of comorbid somatic symptoms].

Zhonghua yi xue za zhi·2026
Same author

[Analysis of current research on recurrent sudden sensorineural hearing loss].

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery·2025
Same author

[Preliminary analysis of risk factors of tinnitus related to female menopause].

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery·2024
Same author

[Progress and future of otological medicine].

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery·2024
Same author

[Reclassification of flat type sudden deafness].

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery·2023
Same journal

Does prior percutaneous coronary revascularization negatively affect the outcomes of subsequent coronary artery bypass grafting?

The Annals of thoracic surgery·2026
Same journal

Lymph Node Dissection and Chylothorax - Balancing Oncologic Benefit Against Morbidity.

The Annals of thoracic surgery·2026
Same journal

Preserved Antegrade Pulmonary Blood Flow in Bidirectional Glenn: Outcomes and Considerations for Staged Palliation.

The Annals of thoracic surgery·2026
Same journal

Domo Arigato, Mr. Roboto.

The Annals of thoracic surgery·2026
Same journal

Impact of High SUVmax on Recurrence by Resection Strategy in Stage IA Adenocarcinoma ≤2 cm.

The Annals of thoracic surgery·2026
Same journal

Preoperative Treatment for Stage II NSCLC Requires Multidimensional Consideration.

The Annals of thoracic surgery·2026
See all related articles

New polyurethane heart valves for artificial hearts show promising durability and biocompatibility. These bistable valves functioned for up to 1 year in sheep without thromboembolism, indicating potential for long-term use.

Area of Science:

  • Biomaterials Science
  • Cardiovascular Engineering
  • Medical Device Development

Background:

  • Artificial heart development requires durable and biocompatible valve components.
  • Existing polyurethane valves face challenges with aging and material degradation.
  • Thromboembolism remains a significant risk in artificial heart recipients.

Purpose of the Study:

  • To evaluate the performance and biocompatibility of novel polyurethane tricuspid semilunar valves for artificial hearts.
  • To assess the durability and thromboembolic risk associated with these advanced heart valves.
  • To compare the aging properties of polyurethane valves with Silastic alternatives.

Main Methods:

  • Fabrication of tricuspid semilunar heart valves using polyurethane.

Related Experiment Videos

  • In vitro accelerated testing simulating 1,000 closures per second using an air jet.
  • In vivo implantation in sheep for up to 1 year to monitor for thromboembolism.
  • Regurgitation assessment using a specialized apparatus with a competent valve.

    • Main Results:

    • Polyurethane valves demonstrated functionality in artificial hearts for up to 62 days.
    • No evidence of thromboembolism was observed in sheep implanted with the valves for 1 year.
    • The valves feature a wide opening with bistable, redundant leaflets designed for enhanced performance.
    • Accelerated testing confirmed high closure rates, and regurgitation was effectively measured.

    Conclusions:

    • The developed polyurethane heart valves exhibit promising long-term biocompatibility and durability for artificial heart applications.
    • The bistable leaflet design and robust performance suggest a reduced risk of thromboembolism.
    • While polyurethanes degrade over time, Silastic presents a non-degrading alternative for future valve development.