Related Experiment Video
Updated: Mar 13, 2026

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice
Published on: March 15, 2019
Hyperoxia Extends Time to Exhaustion During High-Intensity Intermittent Exercise: a Randomized, Crossover Study in
Toshiyuki Ohya1, Ryo Yamanaka2, Hayato Ohnuma2
1Department of Sports Science, Japan Institute of Sports Sciences, Tokyo, 115-0056, Japan. toshiyuki.ohya@jpnsport.go.jp.
Background:
Some endurance athletes exhibit exercise-induced arterial hypoxemia during high-intensity exercise. Inhalation of hyperoxic gas during exercise has been shown to counteract this exercise-associated reduction in hemoglobin oxygen saturation (SaO2), but the effects of hyperoxic gas inhalation on performance and SaO2 during high-intensity intermittent exercise remain unclear. This study investigated the effects of hyperoxic gas inhalation on performance and SaO2 during high-intensity intermittent cycling exercise.
Methods:
Eight male cyclists performed identical intermittent exercise tests (five sets of 3-min high-intensity cycling alternated with 3-min active recovery periods) under two different inspired air conditions, hyperoxia (HO; FIO2 = 0.36) and normoxia (NO; FIO2 = 0.21). The fifth set of each test was terminated at exhaustion, and the exercise time to exhaustion was recorded. Variables associated with arterial oxygen saturation (SpO2) were measured using an ear pulse oximeter.
Results:
Time to exhaustion under HO conditions was significantly longer than under NO conditions (34.9 ± 4.6 vs. 30.0 ± 2.5 min, P = 0.004, ES = 1.32). SpO2 was maintained under HO conditions but decreased under NO conditions.
Conclusions:
Hyperoxic gas inhalation during the entire high-intensity intermittent exercise enhanced exercise performance in male cyclists.
More Related Videos
08:44Author Spotlight: Integrating Alveolar-Capillary Reserve Measurements in Exercise Adaptation and Therapeutic Strategies
Published on: February 2, 2024
05:45Delivery of In Vivo Acute Intermittent Hypoxia in Neonatal Rodents to Prime Subventricular Zone-derived Neural Progenitor Cell Cultures
Published on: November 2, 2015
Related Concept Videos
Oxygen Transport in the Blood
Hypoxia
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
Hyperpnea and Hyperventilation
Acute Respiratory Failure-II
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
Factors Affecting Respiration