[The influence of heat shock proteins on hepatic ischaemia reperfusion injury]

Hepatic ischemia-reperfusion injury as a result of inflow obstruction is a major cause of morbidity and mortality associated with liver pathologies and surgery. Heat shock proteins, a family of stress-inducible proteins involved in maintaining cell homeostasis and regulating the immune system play a major role in liver regeneration. They serve as crucial indicators of ischemia-reperfusion injury in human liver and influence liver function and recovery. The primary objectives of this article are to review the potential role of heat shock proteins as a diagnostic marker for liver diseases and therapeutic target in critical illness. The review will start by focusing on the essentials of heat shock proteins as an endogenous system as it relates to hepatic injury. It will elucidate the influence of heat shock protein-70 on hepatic diseases and ischemia-reperfusion. It will then look at their potential diagnostic role and finally highlights its activities as a possible therapeutic tool. Orv. Hetil., 2016, 157(42), 1659-1666.