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Related Concept Videos

The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...
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The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
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Ageing in the musculoskeletal system.

Sally Roberts1, Pauline Colombier2, Aneka Sowman3

  • 1a Spinal Studies and ISTM , Keele University, and Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation Trust , Oswestry , UK.

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|October 18, 2016
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Summary

Ageing affects the musculoskeletal system, leading to bone loss and cartilage degradation, impacting mobility and quality of life. This review examines cellular changes in the ageing skeleton, drawing from the 2015 Aarhus Regenerative Orthopaedic Symposium (AROS).

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Area of Science:

  • Orthopaedics and Regenerative Medicine
  • Skeletal Biology and Ageing
  • Cellular and Molecular Biology

Background:

  • Musculoskeletal ageing is characterized by bone loss, articular cartilage degradation, and intervertebral disc degeneration.
  • These age-related changes significantly impair mobility and reduce quality of life.
  • Understanding cellular alterations within the ageing skeletal microenvironment is crucial for developing regenerative strategies.

Purpose of the Study:

  • To review the cellular constituents of key musculoskeletal components.
  • To summarize discussions from the 2015 Aarhus Regenerative Orthopaedic Symposium (AROS) on ageing populations.
  • To elucidate how specific cell types change within the ageing skeletal microenvironment.

Main Methods:

  • Literature review of cellular constituents in musculoskeletal tissues.
  • Synthesis of discussions from the 2015 AROS meeting focused on regeneration in ageing.
  • Analysis of cellular alterations in the context of the ageing skeletal microenvironment.

Main Results:

  • Ageing impacts various cell types within bone, cartilage, and intervertebral discs.
  • Specific cellular changes contribute to the functional decline of the musculoskeletal system.
  • The symposium highlighted the need for targeted regenerative approaches based on cellular ageing.

Conclusions:

  • Cellular changes are central to musculoskeletal ageing and its associated pathologies.
  • Regenerative orthopaedics must consider the specific cellular microenvironment alterations during ageing.
  • Further research into cell-specific ageing mechanisms can inform interventions to improve skeletal health and longevity.