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Updated: Mar 13, 2026
Isolation and Characterization of Mesenchymal Stromal Cells from Human Umbilical Cord and Fetal Placenta
Published on: April 3, 2017
BDNF expression is up-regulated by progesterone in human umbilical cord mesenchymal stem cells
Jie Yang1, Xianying Wang1, Sha Liu2
1a Department of Pharmacy , The Third Hospital of Hebei Medical University , Shijiazhuang , China.
Objective:
To investigate whether promotion of neuronal differentiation of human umbilical cord mesenchymal stem cells (HUMSCs) by progesterone (PROG) involves changes in brain-derived neurotrophic factor (BDNF) levels.
Methods:
We used rat brain tissue extracts to mimic the brain microenvironment. Quantitative sandwich enzyme-linked immunosorbent assay was performed to measure levels of BDNF in cultured medium with or without PROG.
Results:
Progesterone increased levels of BDNF in HUMSCs.
Conclusion:
Progesterone enhancement of brain-derived neurotrophic factor levels may be involved in PROG activated-pathways to promote neuronal differentiation of HUMSCs.
