Related Experiment Video
Updated: Mar 13, 2026
08:17
Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
Published on: August 25, 2017
11.6K
Phenomenology of COPD: interpreting phenotypes with the ECLIPSE study.
Alberto Papi1, Maria Sandra Magnoni, Carmelo Caio Muzzio
1University of Ferrara. ppa@unife.it.
Summary
The Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE) study advanced understanding of Chronic Obstructive Pulmonary Disease (COPD) heterogeneity. It identified patient subtypes to predict disease progression and treatment needs.
Area of Science:
- Pulmonary Medicine
- Clinical Research
- Biomarker Discovery
Background:
- Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous condition.
- Understanding COPD heterogeneity is crucial for personalized treatment and prognosis.
- Previous studies lacked comprehensive longitudinal data to define COPD subtypes.
Purpose of the Study:
- To define COPD phenotypes using longitudinal data.
- To identify biomarkers and genetic parameters for predicting COPD progression.
- To characterize clinically important COPD patient subtypes.
Main Methods:
- A 3-year, observational, multicentre international study (ECLIPSE).
- Analysis of metabolomic, proteomic, and genomic data.
- Integration of multi-omics data with clinical prognosis and treatment response.
Main Results:
- Characterization of clinically relevant COPD subtypes, including frequent exacerbators and patients with systemic inflammation.
- Identification of patient groups with potentially different prognoses and treatment requirements.
- Advancement in phenotyping COPD heterogeneity through longitudinal analysis.
Conclusions:
- The ECLIPSE study significantly improved the understanding of COPD heterogeneity.
- Phenotyping based on longitudinal data aids in predicting disease progression.
- Integration of multi-omics data holds promise for personalized COPD management.
Related Concept Videos
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
3.3K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
3.3K
02:27Background and Environment Affect Phenotype
8.0K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
8.0K
01:11Genetic Lingo
116.7K
Overview
116.7K
01:20COPD: Pathogenesis and Clinical Features
2.1K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
2.1K
01:09Epistasis Analysis
6.1K
Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
6.1K
01:33Pleiotropy
43.8K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
43.8K