Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gas Chromatography–Mass Spectrometry (GC–MS)01:14

Gas Chromatography–Mass Spectrometry (GC–MS)

6.1K
Gas chromatography–mass spectrometry (GC–MS) is the combination of analytical techniques of gas chromatography and mass spectrometry in a single instrument for analyzing a mixture of compounds. The gas chromatograph separates the compounds in the mixture, and the mass spectrometer analyzes each compound separately to determine the molecular masses and molecular structures.
A gas chromatograph consists of a long, narrow capillary column with a polysiloxane coating on the inner wall....
6.1K
Gas Chromatography: Sample Injection Systems01:08

Gas Chromatography: Sample Injection Systems

1.2K
In gas chromatography, the sample is introduced as a vapor plug into the carrier gas stream for high efficiency and resolution. A microsyringe injects the sample solution into a heated sample port, vaporizing it and mixing it with the carrier gas. This process is important to ensure the sample is properly prepared for analysis. Thermally sensitive samples can be injected directly into the column and volatilized by slowly increasing the column temperature.
Two primary injection methods are used...
1.2K
Gas Chromatography: Overview of Detectors01:13

Gas Chromatography: Overview of Detectors

1.6K
Detectors in gas chromatography (GC) help identify and quantify the components of a mixture by translating chemical properties into measurable signals, which are displayed on a chromatogram. Detectors can be categorized into two main types: destructive and non-destructive.
A non-destructive detector allows a sample to be analyzed without altering or consuming it, meaning the sample can be collected after detection for further analysis. Examples include thermal conductivity detectors and...
1.6K
Gas Chromatography: Types of Detectors-II01:19

Gas Chromatography: Types of Detectors-II

948
In gas chromatography, different detectors are employed to meet specific analytical needs. These detectors are often categorized based on their detection mechanisms and the types of compounds they are best suited to analyze. Thermal Conductivity Detectors (TCD), Flame Ionization Detectors (FID), and Electron Capture Detectors (ECD) represent common categories, each with unique operating principles and applications. However, beyond these, several other detectors are designed for more specialized...
948
Gas Chromatography: Introduction01:13

Gas Chromatography: Introduction

3.3K
Gas chromatography (GC) is a technique for separating and analyzing volatile compounds in a sample. Its primary purpose is to identify and quantify components in complex mixtures, making it essential in fields such as environmental analysis, pharmaceuticals, and petrochemicals. GC is also called vapor-phase chromatography (VPC) or gas-liquid partition chromatography (GLPC).
In GC,  a sample is vaporized and mixed with an inert carrier gas (the mobile phase), which transports it through a...
3.3K
Gas Chromatography: Types of Detectors-I01:21

Gas Chromatography: Types of Detectors-I

1.2K
There are different types of detectors used in gas chromatography, each with its own specific properties that make it suitable for detecting certain types of analytes. The most commonly used detectors in GC are thermal conductivity detector (TCD), flame ionization detector (FID), and electron capture detector (ECD).
TCD is the earliest and most widely used detector that operates by measuring the changes in the thermal conductivity of the carrier gas. When a sample compound enters the detector,...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fluxomics in precision nutrition: integrating dynamic metabolic profiling with multiomics.

Nutrition (Burbank, Los Angeles County, Calif.)·2026
Same author

Identification of High-Performing Blood Metabolite Biomarkers of Lung Cancer in a Chinese Population.

Phenomics (Cham, Switzerland)·2026
Same author

Automated, targeted, NMR spectral profiling of human breast milk.

Metabolomics : Official journal of the Metabolomic Society·2026
Same author

Serum metabolomic profiling reveals LysoPC/PC depletion as a potential biomarker to detect avian reoviral infection in neonatal broiler chickens.

Frontiers in cellular and infection microbiology·2026
Same author

The NMR Exchange Format (NEF): Specification and Applications.

bioRxiv : the preprint server for biology·2026
Same author

A scoring system for validity assessment of biomarkers of food intake.

Critical reviews in food science and nutrition·2026

Related Experiment Video

Updated: Dec 12, 2025

Measuring Dissolved Methane in Aquatic Ecosystems Using An Optical Spectroscopy Gas Analyzer
05:00

Measuring Dissolved Methane in Aquatic Ecosystems Using An Optical Spectroscopy Gas Analyzer

Published on: July 26, 2024

829

Nano-Optomechanical Systems for Gas Chromatography.

Anandram Venkatasubramanian1,2, Vincent T K Sauer1,2, Swapan K Roy1,3

  • 1National Institute for Nanotechnology , Edmonton, Alberta T6G 2M9, Canada.

Nano Letters
|October 18, 2016
PubMed
Summary

Nano-optomechanical systems (NOMS) offer ultrasensitive mass detection for portable gas chromatography. This technology enables sensitive detection of volatile organic compounds and metabolites for disease diagnosis and personalized medicine.

Keywords:
NOMSgas chromatographygas sensingmetabolite detection

More Related Videos

On-line Analysis of Nitrogen Containing Compounds in Complex Hydrocarbon Matrixes
07:49

On-line Analysis of Nitrogen Containing Compounds in Complex Hydrocarbon Matrixes

Published on: August 5, 2016

11.0K
Fabrication and Testing of Microfluidic Optomechanical Oscillators
09:10

Fabrication and Testing of Microfluidic Optomechanical Oscillators

Published on: May 29, 2014

12.5K

Related Experiment Videos

Last Updated: Dec 12, 2025

Measuring Dissolved Methane in Aquatic Ecosystems Using An Optical Spectroscopy Gas Analyzer
05:00

Measuring Dissolved Methane in Aquatic Ecosystems Using An Optical Spectroscopy Gas Analyzer

Published on: July 26, 2024

829
On-line Analysis of Nitrogen Containing Compounds in Complex Hydrocarbon Matrixes
07:49

On-line Analysis of Nitrogen Containing Compounds in Complex Hydrocarbon Matrixes

Published on: August 5, 2016

11.0K
Fabrication and Testing of Microfluidic Optomechanical Oscillators
09:10

Fabrication and Testing of Microfluidic Optomechanical Oscillators

Published on: May 29, 2014

12.5K

Area of Science:

  • Analytical Chemistry
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Portable chemical analysis using microgas chromatography (GC) is a growing field.
  • Ultrasensitive mass detection is crucial for analyzing trace amounts of substances.
  • Existing methods may lack the sensitivity or portability required for certain applications.

Purpose of the Study:

  • To demonstrate a nano-optomechanical system (NOMS) as an ultrasensitive mass detector for gas chromatography.
  • To evaluate the sensitivity and selectivity of NOMS for volatile organic compounds and metabolites.
  • To explore the potential of NOMS in next-generation metabolite analysis for disease diagnosis and personalized medicine.

Main Methods:

  • Utilized a nano-optomechanical system (NOMS) with bare, native oxide, silicon surfaces as a detector in a microgas chromatography setup.
  • Investigated the sensing capabilities of NOMS for volatile organic compounds at parts per million (ppm) levels.
  • Analyzed GC peaks from derivatized metabolites at physiological concentrations.
  • Explored temperature-dependent adsorption kinetics to enhance signal amplification.

Main Results:

  • Demonstrated that bare silicon surfaces in NOMS can detect volatile organic compounds at ppm levels with chemical selectivity.
  • Successfully sensed GC peaks from derivatized metabolites at physiological concentrations.
  • Achieved a limit of detection as low as 1 part per billion (ppb) without partition enhancement.
  • Showcased the optical microring's dual role as a nanomechanical signal transducer and analyte concentration sensor.

Conclusions:

  • NOMS represent a significant advancement for ultrasensitive mass detection in microgas chromatography.
  • The demonstrated sensitivity and selectivity position NOMS as a promising universal detector for various chemical-sensing applications.
  • This technology holds great potential for applications in breath analysis, disease diagnosis, and personalized medicine through advanced metabolite analysis.