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Perforation complicating rifampin-associated pseudomembranous enteritis
D L Miller1, J D Sedlack, R W Holt
1Georgetown University Surgical Division, District of Columbia General Hospital, Washington, DC 20007.
Abstract:
An 18-year-old man developed a perforated jejunum while receiving rifampin antituberculous chemotherapy. The perforations were located within longitudinal ulcers characteristic of pseudomembranous enterocolitis. Pseudomembranous inflammation was limited to the small intestine. The absence of colonic involvement delayed establishment of the diagnosis. Successful surgical intervention consisting of small-bowel resection with primary anastomosis was accomplished for this rare and potentially fatal complication of antituberculous chemotherapy.
Insights
A rare complication of antituberculous chemotherapy, perforated jejunum occurred in an 18-year-old man. This case highlights pseudomembranous enterocolitis, a serious condition requiring surgical intervention.
Area of Science:
- Gastroenterology
- Infectious Diseases
- Pharmacology
Background:
- Antituberculous chemotherapy, particularly with rifampin, can lead to gastrointestinal complications.
- Pseudomembranous enterocolitis is a severe inflammation of the intestines, often associated with antibiotic use.
- Small intestinal involvement without colonic signs can complicate diagnosis.