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Central Poststroke Pain Can Occur With Normal Sensation.

Ajit Kumar1, Sanjeev K Bhoi, Jayantee Kalita

  • 1Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

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Central poststroke pain (CPSP) affects over 20% of stroke survivors. This study found CPSP can occur even with normal spinothalamic sensations, and pregabalin showed good response in half of patients.

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Area of Science:

  • Neurology
  • Pain Medicine
  • Stroke Research

Background:

  • Central poststroke pain (CPSP) is a debilitating condition with limited research.
  • Understanding CPSP's frequency and characteristics is crucial for patient management.

Purpose of the Study:

  • To evaluate the frequency, clinical spectrum, imaging, and sensory findings in stroke patients with CPSP.
  • To assess the efficacy of pregabalin in managing CPSP symptoms.

Main Methods:

  • Prospective hospital-based study of 319 stroke patients.
  • Clinical evaluation, quantitative sensory testing, and imaging.
  • Pregabalin treatment (150-600 mg/d) assessed for >50% VAS score improvement.

Main Results:

  • CPSP occurred in 20.7% of patients.
  • Pain characteristics varied; no correlation with demographics or lesion site.
  • Half of patients responded well to pregabalin.

Conclusions:

  • CPSP prevalence is significant, affecting over 20% of stroke survivors.
  • Spinothalamic tract dysfunction is not essential for CPSP development.
  • Pregabalin offers a viable treatment option for CPSP.