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Generation of Natural Killer Cells from Human Expanded Potential Stem Cells
Published on: January 13, 2023
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Requirements for human natural killer cell development informed by primary immunodeficiency.
1Center for Human Immunobiology, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas, USA.
Current Opinion in Allergy and Clinical Immunology
|October 27, 2016
Summary
Primary immunodeficiencies reveal critical needs for human natural killer (NK) cell development. Understanding these deficiencies is key to improving NK cell maturation and immune health.
Area of Science:
- Immunology
- Cell Biology
- Genetics
Background:
- Human natural killer (NK) cell development is not fully understood.
- Primary immunodeficiencies offer insights into NK cell generation and function.
Purpose of the Study:
- To review monogenic primary immunodeficiencies impacting human NK cell development.
- To highlight critical requirements for mature NK cell subset generation and homeostasis.
Main Methods:
- Review of existing literature on primary immunodeficiencies affecting NK cells.
- Analysis of NK cell phenotyping data in patients with immunodeficiencies.
Main Results:
- Specific genetic defects lead to deficiencies in NK cell subsets.
- These deficiencies impact NK cell distribution, maturation, and homeostasis.
- NK cell deficiencies are associated with severe viral susceptibility.
Conclusions:
- Monogenic primary immunodeficiencies are crucial for understanding human NK cell development.
- NK cells play a vital, nonredundant role in controlling viral infections.
- Defects in NK cell subsets, even with normal total numbers, impair immune function.
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