Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Electroconvulsive Therapy01:30

Electroconvulsive Therapy

1.7K
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The utility of caffeine citrate as a neuroprotectant in the early life of premature newborns: a literature review of the effects on neurodevelopmental outcomes.

Frontiers in pediatrics·2026
Same author

Transarterial embolization versus hemispherectomy in infants with hemimegalencephaly and drug-resistant epilepsy.

Pediatric research·2025
Same author

Transarterial embolization for infants under 3 months of age with refractory seizures due to hemimegalencephaly: complication analysis and evolution of treatment strategy.

Journal of neurointerventional surgery·2025
Same author

The American Clinical Neurophysiology Society Guideline on Indications for Continuous Electroencephalography Monitoring in Neonates.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society·2025
Same author

Electroencephalographic Patterns on Follow-Up Visits in Extremely Premature Infants With Periventricular Leukomalacia: An Observational Study.

Pediatric neurology·2024
Same author

Stimulation of the pulvinar nucleus of the thalamus in epilepsy: A systematic review and individual patient data (IPD) analysis.

Clinical neurology and neurosurgery·2023

Related Experiment Video

Updated: Mar 13, 2026

Application of an Amplitude-integrated EEG Monitor Cerebral Function Monitor to Neonates
05:58

Application of an Amplitude-integrated EEG Monitor Cerebral Function Monitor to Neonates

Published on: September 6, 2017

40.9K

Treatment Effects on Neonatal EEG.

Rawad Obeid1, Tammy N Tsuchida

  • 1Department of Neurology, Children's National Health System, Washington, District of Columbia, U.S.A.

Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society
|October 18, 2016
PubMed
Summary

Neuroactive medications and hypothermia can alter neonatal electroencephalography (EEG) interpretation. Understanding these effects is crucial for accurate prognostication in newborns receiving these therapies.

More Related Videos

Preterm EEG: A Multimodal Neurophysiological Protocol
19:32

Preterm EEG: A Multimodal Neurophysiological Protocol

Published on: February 18, 2012

29.1K
Author Spotlight: Assessing the Feasibility of Using Amplitude-Integrated EEG During Neonatal Transport
05:15

Author Spotlight: Assessing the Feasibility of Using Amplitude-Integrated EEG During Neonatal Transport

Published on: June 21, 2024

1.5K

Related Experiment Videos

Last Updated: Mar 13, 2026

Application of an Amplitude-integrated EEG Monitor Cerebral Function Monitor to Neonates
05:58

Application of an Amplitude-integrated EEG Monitor Cerebral Function Monitor to Neonates

Published on: September 6, 2017

40.9K
Preterm EEG: A Multimodal Neurophysiological Protocol
19:32

Preterm EEG: A Multimodal Neurophysiological Protocol

Published on: February 18, 2012

29.1K
Author Spotlight: Assessing the Feasibility of Using Amplitude-Integrated EEG During Neonatal Transport
05:15

Author Spotlight: Assessing the Feasibility of Using Amplitude-Integrated EEG During Neonatal Transport

Published on: June 21, 2024

1.5K

Area of Science:

  • Neonatal neurology
  • Clinical neurophysiology

Background:

  • Conventional electroencephalography (EEG) and amplitude-integrated EEG (aEEG) are vital for assessing neonatal brain activity and prognosis.
  • Neuroactive medications and therapeutic hypothermia are common in neonates but can impact EEG interpretation.
  • Limited research exists on how these interventions affect neonatal EEG background activity.

Purpose of the Study:

  • To review the effects of neuroactive medications and therapeutic hypothermia on neonatal EEG and aEEG.
  • To highlight the importance of considering these effects for accurate interpretation and prognostication.

Main Methods:

  • Literature review of studies examining the impact of neuroactive medications and therapeutic hypothermia on neonatal EEG and aEEG.
  • Analysis of reported changes in EEG patterns, including interburst interval, voltage suppression, and sleep disruption.

Main Results:

  • Neuroactive medications can cause transient or persistent changes in EEG, such as increased interburst intervals and voltage suppression, particularly in premature infants.
  • Therapeutic hypothermia does not significantly alter EEG activity itself but affects the timing of EEG-based neurodevelopmental outcome prediction.

Conclusions:

  • Accurate interpretation of neonatal EEG and aEEG requires accounting for the influence of neuroactive medications and therapeutic hypothermia.
  • Failure to consider these effects can lead to misinterpretation and inaccurate prognostication in neonatal care.