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Related Concept Videos

Primary Lymphoid Organs01:16

Primary Lymphoid Organs

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Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
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Secondary Lymphoid Organs01:15

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Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
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Updated: Mar 13, 2026

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma
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Multifocal extranodal lymphoma: A case report.

Chao Li1, Lin Li, Ping Zhang

  • 1Department of Oncology, Beijing Hospital Department of Pathology, Beijing Hospital Cancer Hospital, Chinese Academy of Medical Science Department of Nuclear Medicine, Beijing Hospital, Beijing, China.

Medicine
|October 18, 2016
PubMed
Summary
This summary is machine-generated.

A rare non-Hodgkin lymphoma case involved seven extranodal sites. Positron emission tomography/computed tomography aided diagnosis and response assessment, though optimal treatment requires further study.

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Area of Science:

  • Oncology
  • Hematology
  • Radiology

Background:

  • Non-Hodgkin lymphoma (NHL) can present with extranodal involvement.
  • Diffuse large B-cell lymphoma (DLBCL) is an aggressive subtype of NHL.

Observation:

  • A 43-year-old woman presented with DLBCL affecting seven extranodal sites: stomach, breasts, pancreas, adrenal glands, ovary, and bones.
  • Diagnosis was confirmed via biopsy and positron emission tomography/computed tomography (PET/CT).

Findings:

  • The patient achieved complete response after two cycles of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP) chemotherapy.
  • Central nervous system (CNS) involvement developed subsequently, highlighting potential treatment challenges.

Implications:

  • PET/CT is valuable for diagnosing, staging, and assessing treatment response in extranodal lymphoma.
  • Optimal therapeutic strategies for extensive extranodal DLBCL, especially concerning CNS relapse, require further investigation.