Related Experiment Video
Updated: Mar 13, 2026

Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals
Published on: January 5, 2016
T-cell Activation and E-selectin Are Associated With Coronary Plaque in HIV-infected Young Adults
Aviva S Mattingly1, Aylin B Unsal, Julia B Purdy
1From the *Laboratory of Immunoregulation, National Institute of Allergy and Infectious Disease (NIAID), Bethesda, Maryland; †Critical Care Medicine Department, National Institutes of Health (NIH) Clinical Center, Bethesda, Maryland; ‡Biomedical and Metabolic Imaging Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Bethesda, Maryland; §AIDS Monitoring Laboratories, Frederick National Laboratory for Cancer Research Leidos Biomedical Research, Inc., Frederick, Maryland; and ¶Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Bethesda, Maryland.
Abstract:
We evaluated immune activation and coronary artery plaque in young adults with human immunodeficiency virus acquired in early life (n = 31). Coronary plaque was positively associated with lipids, immune activation marker %CD8+CD38+DR+ and E-selectin, a marker of endothelial inflammation. Immune activation and endothelial inflammation may drive coronary plaque formation during the early stages of atherosclerosis in the context of chronic human immunodeficiency virus.
More Related Videos
09:41Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions
Published on: October 17, 2017
08:11Assessing the Innate Sensing of HIV-1 Infected CD4+ T Cells by Plasmacytoid Dendritic Cells Using an Ex vivo Co-culture System.
Published on: September 1, 2015
Related Concept Videos
T Cell Activation and Clonal Selection
Naive T cells that have not yet encountered an antigen express two primary CD...
Coronary Artery Disease II: Pathophysiology
Atherosclerosis I: Introduction
Selectins
Coronary Artery Disease III: Clinical Manifestations
Inflammation