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Piperacillin-Tazobactam-induced Adverse Drug Events in Pediatric Patients on Outpatient Parenteral Antimicrobial
Dawood Yusef1, Blanca E Gonzalez, Charles B Foster
1*Department of Pediatrics, Jordan University of Science and Technology, Irbid, Jordan; †Center for Pediatric Infectious Diseases, Cleveland Clinic Children's, Cleveland, Ohio; and ‡Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio.
Abstract:
We report a significantly higher occurrence of adverse events associated with prolonged courses of piperacillin-tazobactam compared with other antibacterial agents used for pediatric outpatient parenteral antimicrobial therapy. These adverse events were characterized by a constellation of clinical findings including fever, hematologic abnormalities and transaminitis. Adverse events related to piperacillin-tazobactam should be considered in patients who develop a febrile illness associated with a prolonged course of therapy.
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