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The Cost-efficiency and Care Effectiveness of Probiotic Administration with Antibiotics to Prevent Hospital-Acquired
Emily S Starn1, Holly Hampe, Thomas Cline
11203 Dutilh Rd Unit 8, Cranberry Township, Pennsylvania (Dr Starn); School of Nursing and Health Sciences, Robert Morris University, Moon Township, Pennsylvania (Dr Hampe); and Alex G. McKenna School of Business, Saint Vincent College, Latrobe, Pennsylvania (Dr Cline).
Abstract:
Health care facility-acquired Clostridium difficile infections (HCFA-CDI) have increased over the last several decades despite facilities developing protocols for prescribing probiotics with antibiotics to prevent HCFA-CDI. The literature does not consistently support this. A retrospective medical record review evaluated the care effectiveness of this practice. Care effectiveness was not found; patients receiving probiotics with antibiotics were twice as likely to develop HCFA-CDI (P = .004). Except with glycopeptides, patients were 1.88 times less likely to experience HCFA-CDI (P = .05).
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