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Vitamin D and depression.

Gordon B Parker1, Heather Brotchie1, Rebecca K Graham1

  • 1School of Psychiatry, University of New South Wales, Sydney, NSW, Australia; Black Dog Institute, Sydney, NSW, Australia.

Journal of Affective Disorders
|October 18, 2016
PubMed
Summary
This summary is machine-generated.

Research suggests a link between low vitamin D levels and depression. Vitamin D supplementation may help treat depression in deficient individuals, but more research is needed.

Keywords:
AugmentationDepressionSupplementationTreatmentVitamin D

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Area of Science:

  • Nutritional Neuroscience
  • Psychiatry
  • Endocrinology

Background:

  • Vitamin D deficiency and insufficiency are potential contributing factors to depression.
  • The role of vitamin D in mental health is an area of growing scientific interest.

Purpose of the Study:

  • To investigate the association between vitamin D status and depression.
  • To evaluate the efficacy of vitamin D supplementation as a treatment for depression.

Main Methods:

  • Systematic review of empirical studies from PubMed, Google Scholar, and Cochrane Database.
  • Search terms included 'vitamin D', 'depression', and 'treatment'.
  • Emphasis on recent publications (post-2011) with consideration of earlier relevant studies.

Main Results:

  • Increasing evidence supports an association between vitamin D insufficiency and depression.
  • Vitamin D supplementation shows promise as an adjunctive treatment for depressed individuals with vitamin D deficiency.
  • Methodological limitations in existing studies were identified.

Conclusions:

  • Further high-quality, randomized controlled longitudinal trials are necessary.
  • Clarify vitamin D's role in depression pathogenesis and management.
  • Determine the clinical significance and distinctiveness of observed associations.