Processing and strengthening of 58S bioactive glass-infiltrated titania scaffolds

In this work, TiO₂ ceramic scaffolds were fabricated by the replica method using polyurethane (PU) sponges. Suspensions with high solid content were used to achieve scaffolds with improved mechanical behavior. TiO₂ ceramic suspensions were optimized by rheological studies using different additives. It was found that the composition with 0.5 wt % Darvan enhanced the covering of the sponge struts. PU sponges of 45 to 80 ppi (pore per inch) were well coated without clogging pores. A thermal treatment with varying holding times, temperatures and heating rates was adjusted. The influence of different pore sizes on mechanical strength was evaluated. It was possible to obtain TiO₂ scaffolds with 90% porosity and high pore interconnectivity, having compressive strength exceeding 0.6 MPa. TiO₂ scaffolds were filled up with a 58S bioactive glass suspension to impart bioactive character to the scaffolds. These hybrid structures presented mechanical strengthening of about 26-213% depending on their sponge porosity. The prediction for cells viability via zeta potential measures indicated that this hybrid material is very promising for scaffold application with -19 to -25 mV between pH of 7.35-7.45. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 590-600, 2017.