Related Experiment Video

Updated: Mar 13, 2026

Implantation of Total Artificial Heart in Congenital Heart Disease
07:27

Implantation of Total Artificial Heart in Congenital Heart Disease

Published on: July 18, 2014

25.3K

Cognitive dysfunction in adult CHD with different structural complexity

Manavi Tyagi1, Theodora Fteropoulli1, Catherine S Hurt1

  • 11Centre for Health Services Research,School of Health Sciences,City University London,London,United Kingdom.

Cardiology in the Young
|October 19, 2016
PubMed

Insights

Adults with congenital heart disease (CHD) often experience impaired cognitive function, particularly in attention and executive functions. Cognitive deficits are linked to the complexity of the heart condition, impacting clinical care decisions.

Area of Science:

  • Cardiology
  • Neuropsychology
  • Developmental Pediatrics

Background:

  • Adult congenital heart disease (CHD) requires ongoing management, with growing attention to long-term neurodevelopmental outcomes.
  • Cognitive function is a crucial aspect of quality of life and functional independence in adults.

Purpose of the Study:

  • To assess cognitive function in a cohort of adult CHD patients.
  • To investigate the relationship between cognitive performance and the structural complexity of congenital heart disease.

Main Methods:

  • A cross-sectional study involving 310 adult CHD patients.
  • Neuropsychological assessments evaluated memory, executive function, and divided attention.
  • Patients were categorized into four groups based on disease complexity: tetralogy of Fallot, transposition of the great arteries, single ventricle, and simple conditions.

Main Results:

  • 41% of adult CHD patients exhibited impaired cognitive function, significantly higher than the expected 8% in the general population.
  • Deficits were noted in divided attention, motor function, and executive functioning.
  • Cognitive performance, including divided attention and overall composite scores, varied significantly across disease complexity groups, with simpler conditions associated with better outcomes.

Conclusions:

  • Adult CHD patients frequently present with cognitive impairments compared to healthy individuals.
  • The degree of cognitive dysfunction is associated with the complexity of the underlying congenital heart defect.
  • Findings underscore the need for tailored clinical strategies and further research into the mechanisms and mitigation of cognitive deficits in adult CHD.
Abstract

Keywords:
Adult CHDcognitionmoodneuropsychological assessment

More Related Videos

Creation of Patient-Specific Silicone Cardiac Models with Applications in Pre-surgical Plans and Hands-on Training09:15

Creation of Patient-Specific Silicone Cardiac Models with Applications in Pre-surgical Plans and Hands-on Training

Published on: February 10, 2022

4.3K
A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance09:01

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

Published on: May 7, 2014

10.6K

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.2K
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
702
Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
520
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
3.4K
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
611
Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
1.0K