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Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System
Published on: October 22, 2020
A Paradox: α-Klotho Levels and Smoking Intensity
Zoraida Verde1, Jose M Rodríguez González-Moro2, Luis M Chicharro3
1Department of Biomedical Sciences, Universidad Europea, 28670, Villaviciosa de Odón, Madrid, Spain. zoraida.verde@universidadeuropea.es.
Abstract:
Reports regarding smoking differences in α-klotho expression have provided conflicting results. In the current study we focused on the influence of smoking intensity to serum levels of the aging molecule α-klotho in healthy smokers. 40 middle aged healthy smokers without airway obstruction or restriction were selected for the analysis. Serum levels of soluble α-klotho were significantly higher in heavy smokers (P < 0.001). These results are in agreement with the possibility that α-klotho acts as anti-inflammatory molecule and strengthen the hypothesis that an increase of serum levels of α-klotho might be a compensatory response to smoking stress in healthy population.
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