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Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Fractalkine in obstructive sleep apnea patients
Gulgun Cetintas Afsar1, Ozlem Oruc2, Sema Sarac2
1Department of Pulmonology, Süreyyapaşa Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul, Turkey. gulguncet@hotmail.com.
Fractalkine levels did not differ between obstructive sleep apnea (OSA) patients and controls. However, PAP treatment significantly reduced fractalkine in OSA patients, suggesting it indicates treatment success.
Area of Science:
- Sleep Medicine
- Inflammation Research
- Biomarker Discovery
Background:
- Obstructive sleep apnea (OSA) affects 2-4% of adults and may involve inflammatory processes.
- Fractalkine (CX3CL1), an inflammatory marker found in various cells, is being investigated for its role in OSA.
- Understanding OSA pathogenesis and potential biomarkers is crucial for effective management.
Purpose of the Study:
- To investigate the role of fractalkine in the pathogenesis of obstructive sleep apnea (OSA).
- To evaluate the impact of positive airway pressure (PAP) treatment on serum fractalkine levels in OSA patients.
Main Methods:
- Compared serum fractalkine levels between 34 OSA patients and 20 healthy controls.
- Assessed changes in serum fractalkine levels in OSA patients after one week of PAP treatment.
Main Results:
- No significant difference in baseline serum fractalkine levels was observed between OSA patients and healthy controls (p=0.67).
- Serum fractalkine levels significantly decreased in OSA patients following one week of PAP treatment (p=0.001).
Conclusions:
- Fractalkine is not a sensitive diagnostic marker for obstructive sleep apnea (OSA).
- Decreased serum fractalkine levels after PAP treatment suggest fractalkine may indicate treatment efficacy in OSA.
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