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Portable Device for Measuring Breath Acetone Based on Sample Preconcentration and Cavity Enhanced Spectroscopy
Thomas P J Blaikie1, John Couper, Gus Hancock
1Oxford Medical Diagnostics, Ltd. , Centre for Innovation and Enterprise, Begbroke Science Park, Begbroke Hill, Begbroke OX5 1PF, United Kingdom.
Analytical Chemistry
|October 19, 2016
Summary
This study presents a portable breathalyzer for measuring acetone. The compact device uses an optical cavity and preconcentrator, achieving a low detection limit for breath acetone analysis.
Area of Science:
- Analytical Chemistry
- Biomedical Engineering
- Optical Sensing
Background:
- Acetone in breath is a potential biomarker for metabolic states.
- Accurate and portable methods for breath acetone measurement are needed.
Purpose of the Study:
- To demonstrate a portable, compact device for measuring breath acetone.
- To validate the device's performance against established methods.
Main Methods:
- A device integrating an optical cavity sensor and a preconcentrator was developed.
- Near-infrared diode laser spectroscopy probed acetone released from the preconcentrator.
- The system was validated using an ion-molecule reaction mass spectrometer.
Main Results:
- A limit of detection of 159 ppbv was achieved for breath bag samples.
- Direct breath sampling showed a precision of 100 ppbv.
- Elevated breath acetone levels were observed in individuals post-fasting, exercise, and during normal routines.
Conclusions:
- The portable device offers a promising tool for non-invasive breath acetone monitoring.
- The technology enables real-time assessment of metabolic changes via breath analysis.
