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Monomeric (7S) and polymeric (19S) IgM anti-delta in acute and chronic delta infections
S O Vyazov1, I N Khlopova, V V Mesyanzhinov
1Department of Viral Hepatitis and Clinical Virology, D.I. Ivanovsky Institute of Virology, Academy of Medical Sciences USSR, Moscow.
Abstract:
The chromatographic profiles of IgM anti-delta in 45 acute and 24 chronic delta patients were analyzed by fast protein liquid chromatography (FPLC). Predominance of 19S IgM anti-delta was observed in the sera of 100 percent of coinfected and 62% of superinfected patients. In contrast, 7S IgM anti-delta was predominant in 83% of patients with chronic hepatitis delta. The study of the chromatographic profiles of IgM anti-delta in the development of the disease showed an association between the process of chronic delta-infection and the failure of 7S IgM anti-delta monomers to form 19S pentamers. The results showed that the test for 7S and 19S IgM anti-delta could be useful for differential diagnosis of acute and chronic hepatitis delta infection and for determining the prognosis of acute delta infection.