Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

1.9K
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
1.9K
Surface Active Agents01:27

Surface Active Agents

62
Surfactants, named for their behavior at interfaces, positively adsorb at the interfaces of two phases, reducing interfacial tension. Their versatility as emulsifiers, detergents, and foaming agents stems from this ability. Surfactants, often termed amphiphiles, share the property of amphipathy, with molecules having both hydrophilic and hydrophobic portions. The hydrophilic part is called the head, and the hydrophobic part, including an elongated alkyl substituent, forms the tail.Surfactants...
62
Micelles01:30

Micelles

132
Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...
132
Bioavailability Enhancement: Drug Solubility Enhancement01:16

Bioavailability Enhancement: Drug Solubility Enhancement

411
Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
411
Cholinergic Antagonists: Pharmacokinetics01:24

Cholinergic Antagonists: Pharmacokinetics

1.1K
Cholinergic antagonists—such as antimuscarinics—are available in oral, topical, ocular, parenteral, and inhalational formulations. Most antimuscarinics are oral formulations,  while scopolamine is available as a topical patch, and ipratropium and tiotropium are available as inhalation aerosols or powders. Atropine, tropicamide, and cyclopentolate are topically instilled in the eye. Most antimuscarinics are lipid-soluble and readily absorbed from the gastrointestinal tract and...
1.1K
Antiasthma Drugs: Methylxanthines01:24

Antiasthma Drugs: Methylxanthines

1.9K
Theophylline, a member of the methylxanthine class of bronchodilators, has long been used in asthma management. While its exact mechanism of action is not fully understood, it is believed to have multiple effects on various cellular processes.
Theophylline is thought to inhibit phosphodiesterase enzymes, increasing intracellular levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). This rise in cAMP and cGMP concentrations stimulates cardiac function,...
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Noncovalent Bonding in d and f-Type Coordination Compounds and Lattices. A Case Study.

ChemPlusChem·2024
Same author

MeNPs-PEDOT Composite-Based Detection Platforms for Epinephrine and Quercetin.

Biosensors·2024
Same author

Insight into the interaction of quinizarin with SDS micelles -- effects of additives.

Acta chimica Slovenica·2024
Same author

Near-90° Switch in the Polar Axis of Dion-Jacobson Perovskites by Halide Substitution.

Journal of the American Chemical Society·2023
Same author

Effect of SDS Micelles on Actinomycin D - DNA Complexes.

Acta chimica Slovenica·2022
Same author

Surface states mediated charge transfer in redox behavior of hemin at GaAs(100) electrodes.

RSC advances·2022
Same journal

RETRACTED: Atta et al. Effect of Montmorillonite Nanogel Composite Fillers on the Protection Performance of Epoxy Coatings on Steel Pipelines. <i>Molecules</i> 2017, <i>22</i>, 905.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Chen et al. Chemical Composition of <i>Litsea pungens</i> Essential Oil and Its Potential Antioxidant and Antimicrobial Activities. <i>Molecules</i> 2023, <i>28</i>, 6835.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Ruan et al. Comparison of Extraction, Isolation, Purification, Structural Characterization and Immunomodulatory Activity of Polysaccharides from Two Species of <i>Cistanche</i>. <i>Molecules</i> 2025, <i>30</i>, 4754.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Li et al. Gastrodin Ameliorates Cognitive Dysfunction in Vascular Dementia Rats by Suppressing Ferroptosis via the Regulation of the Nrf2/Keap1-GPx4 Signaling Pathway. <i>Molecules</i> 2022, <i>27</i>, 6311.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Zueva et al. Steady-State Kinetics of Enzyme-Catalyzed Hydrolysis of Echothiophate, a P-S Bonded Organophosphorus as Monitored by Spectrofluorimetry. <i>Molecules</i> 2020, <i>25</i>, 1371.

Molecules (Basel, Switzerland)·2026
Same journal

1,4-Diazatriphenylene and Its Hetero-Fused Analogs: Synthesis and Applications.

Molecules (Basel, Switzerland)·2026
See all related articles

Related Experiment Video

Updated: Mar 13, 2026

Microtensiometer for Confocal Microscopy Visualization of Dynamic Interfaces
08:05

Microtensiometer for Confocal Microscopy Visualization of Dynamic Interfaces

Published on: September 9, 2022

3.0K

Mitoxantrone-Surfactant Interactions: A Physicochemical Overview.

Mirela Enache1, Ana Maria Toader2, Madalin Iancu Enache3

  • 1Institute of Physical Chemistry Ilie Murgulescu, Romanian Academy, Splaiul Independentei 202, Bucharest 060021, Romania. enachemir@yahoo.com.

Molecules (Basel, Switzerland)
|October 19, 2016
PubMed
Summary
This summary is machine-generated.

This review explores how the anticancer drug mitoxantrone interacts with surfactants. Understanding these drug-surfactant interactions is key to developing improved drug delivery systems for cancer treatment.

Keywords:
binding constantmicellesmitoxantronepartition coefficientsurfactants

More Related Videos

Synthesis and Reaction Chemistry of Nanosize Monosodium Titanate
08:44

Synthesis and Reaction Chemistry of Nanosize Monosodium Titanate

Published on: February 23, 2016

9.3K
Enhanced Oil Recovery using a Combination of Biosurfactants
13:19

Enhanced Oil Recovery using a Combination of Biosurfactants

Published on: June 3, 2022

6.1K

Related Experiment Videos

Last Updated: Mar 13, 2026

Microtensiometer for Confocal Microscopy Visualization of Dynamic Interfaces
08:05

Microtensiometer for Confocal Microscopy Visualization of Dynamic Interfaces

Published on: September 9, 2022

3.0K
Synthesis and Reaction Chemistry of Nanosize Monosodium Titanate
08:44

Synthesis and Reaction Chemistry of Nanosize Monosodium Titanate

Published on: February 23, 2016

9.3K
Enhanced Oil Recovery using a Combination of Biosurfactants
13:19

Enhanced Oil Recovery using a Combination of Biosurfactants

Published on: June 3, 2022

6.1K

Area of Science:

  • Pharmacology
  • Physical Chemistry
  • Materials Science

Background:

  • Mitoxantrone is a synthetic anticancer drug, developed as a doxorubicin analogue to improve antitumor activity and reduce cardiotoxicity.
  • Anticancer drugs face cell membranes as the initial barrier; surfactant micelles serve as model systems for biological membranes.
  • Studying drug-surfactant interactions offers insights into controlling drug properties for enhanced delivery systems.

Purpose of the Study:

  • To review the physicochemical aspects of mitoxantrone interactions with various surfactants.
  • To discuss binding constants, partition coefficients, and Gibbs free energy of mitoxantrone-micelle interactions.
  • To elucidate the probable location of mitoxantrone molecules within surfactant micelles.

Main Methods:

  • Literature review of studies on mitoxantrone-surfactant interactions.
  • Analysis of reported binding constants and partition coefficients.
  • Discussion of thermodynamic parameters (Gibbs free energy) and drug localization models.

Main Results:

  • Mitoxantrone exhibits varying degrees of interaction with different surfactants, influencing its physicochemical properties.
  • Binding constants and partition coefficients quantify the affinity of mitoxantrone for micellar environments.
  • The Gibbs free energy indicates the spontaneity and stability of mitoxantrone-micelle complex formation.

Conclusions:

  • Understanding mitoxantrone-surfactant interactions is crucial for designing advanced drug delivery systems.
  • Physicochemical characterization of these interactions aids in optimizing drug efficacy and reducing side effects.
  • This knowledge supports the development of novel biomedical applications for mitoxantrone encapsulation.