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Buoyant sustained release granules based on chitosan.

K Inouye1, Y Machida, T Sannan

  • 1Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.

Drug Design and Delivery
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

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New chitosan-based floating granules and laminated preparations were developed for sustained drug release. These formulations demonstrated immediate buoyancy and controlled prednisolone release, showing promise for oral drug delivery systems.

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Chitosan is a versatile biopolymer with potential in drug delivery.
  • Developing sustained-release oral dosage forms remains a challenge.

Purpose of the Study:

  • To develop and characterize intragastric floating granules and laminated preparations using chitosan.
  • To evaluate their drug release properties and in vivo absorption.

Main Methods:

  • Granules and laminates prepared using chitosan with varying deacetylation degrees.
  • Buoyancy and in vitro prednisolone release studies conducted.
  • In vivo drug absorption study performed in beagle dogs.

Main Results:

  • All formulations exhibited immediate buoyancy in acidic and neutral media.

Related Experiment Videos

  • Sustained release of prednisolone was achieved, controllable by chitosan L content or membrane thickness.
  • In vivo studies confirmed sustained drug absorption.

    • Conclusions:

    • Chitosan-based floating granules and laminates are effective for sustained drug delivery.
    • Formulation parameters can be modulated to control drug release kinetics.
    • These systems show potential for improved oral drug absorption.