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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Inflammatory Response I: Vascular and Cellular01:30

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The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

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Chronic Bowel Disorders: Introduction01:17

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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Related Experiment Video

Updated: Mar 13, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
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Vasculitis in the autoinflammatory diseases.

Hagit Peleg1, Eldad Ben-Chetrit

  • 1Rheumatology Unit, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

Current Opinion in Rheumatology
|October 21, 2016
PubMed
Summary
This summary is machine-generated.

Autoinflammatory diseases (AIDs) rarely involve vasculitis, with neutrophilic dermatoses being more common. Vasculitis occurrence in AIDs is often coincidental, not an integral disease feature.

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Area of Science:

  • Immunology
  • Rheumatology
  • Dermatology

Background:

  • Autoinflammatory diseases (AIDs) are characterized by innate immune system dysregulation and unprovoked inflammation.
  • Skin manifestations like rashes are common in AIDs, but vasculitis is infrequently reported.

Purpose of the Study:

  • To review the prevalence and relationship between autoinflammatory diseases and vasculitis.
  • To differentiate between vasculitis and neutrophilic dermatoses in the context of AIDs.

Main Methods:

  • Literature review of studies on autoinflammatory diseases and vasculitis.
  • Analysis of reported cases linking specific AIDs with different types of vasculitis.

Main Results:

  • Neutrophilic dermatoses are more prevalent in AIDs than vasculitis.
  • Large vessel vasculitis is associated with Behcet's and Blau's syndromes.
  • Small and medium vessel vasculitides are rarely seen in specific AIDs like familial Mediterranean fever.

Conclusions:

  • Neutrophilic dermatoses are more common than vasculitis in AIDs, potentially indicating a limited role for IL-1 in vasculitis pathogenesis.
  • The rarity of vasculitis in AIDs suggests it is often coincidental rather than a core feature of the autoinflammatory disease.