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Angiogenesis in the Ischemic Rat Lung

Angiogenesis in the Ischemic Rat Lung

Published on: February 8, 2013

Systemic vasculitis and the lung.

Rosaria Talarico¹, Simone Barsotti, Elena Elefante

¹aRheumatology Unit, University of Pisa, Pisa bDepartment of Medical Biotechnologies, University of Siena, Siena, Italy.

Current Opinion in Rheumatology

|October 19, 2016

Summary

This summary is machine-generated.

Pulmonary involvement in antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) is common. Myeloperoxidase-ANCA-positive AAV, particularly microscopic polyangiitis, shows higher lung involvement rates compared to proteinase 3-ANCA-positive AAV.

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Area of Science:

Pulmonary Medicine
Rheumatology
Immunology

Background:

Lung involvement is a frequent manifestation of systemic vasculitis.
Antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) encompasses conditions like microscopic polyangiitis (MPA).
Pulmonary complications significantly impact patient prognosis in vasculitis.

Purpose of the Study:

To critically analyze recent literature on lung involvement in AAV and non-AAV.
To provide an update on pathogenesis, clinical features, and novel treatments for pulmonary vasculitis.
To focus on studies published within the last year.

Main Methods:

Systematic MedLine search for relevant studies.
Analysis of recent literature on diagnosis, pathogenesis, and treatment.
Critical review of data on lung involvement in ANCA-associated and non-ANCA-associated vasculitis.

Main Results:

Lung involvement is more frequent in myeloperoxidase-ANCA-positive AAV, especially MPA, than in proteinase 3-ANCA-positive AAV.
Non-ANCA-associated vasculitis can present with concerning lung involvement, particularly when vascular disease is present.
Recent literature highlights advances in understanding and managing pulmonary manifestations of vasculitis.

Conclusions:

Pulmonary involvement is a key aspect of AAV and other systemic vasculitides.
Understanding specific ANCA subtypes (MPO-ANCA vs. PR3-ANCA) is crucial for assessing lung risk.
Ongoing research is vital for improving diagnosis and treatment of lung disease in vasculitis.