Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Pulsed Electrical Field Ablation Plus Intratumoral Immunotherapy for Hepatocellular Carcinoma.

Journal of immunotherapy (Hagerstown, Md. : 1997)·2026

Same author

The effect of kinesiology tape on pain reduction in patellofemoral pain syndrome: a systematic review and meta-analysis of randomized controlled trials.

Journal of osteopathic medicine·2026

Same author

Thread carpal tunnel release vs. minimally invasive carpal tunnel release: a systematic review and meta-analysis.

Pain management·2026

Same author

Tranexamic acid can reduce blood loss and improve visibility in otological surgeries: a systematic review and meta-analysis of randomised controlled trials.

The Journal of laryngology and otology·2025

Same author

SEM-EDS and hyperspectral images of vine leaves treated with antifungal products.

Data in brief·2025

Same author

Preoperative cryoneurolysis for peri- and postoperative pain in total knee arthroplasty: a systematic review and pooled analysis.

Pain management·2025

Search research articles

Related Experiment Video

Updated: Mar 13, 2026

Surgical Transplantation of Tumor Cells into the Spinal Cord of Mice

Surgical Transplantation of Tumor Cells into the Spinal Cord of Mice

Published on: December 27, 2024

Cutaneous Metastasis From Sacral Chordoma.

Kristyna Gleghorn¹, Brandon Goodwin, Ramon Sanchez

¹*School of Medicine, University of Texas Medical Branch, Galveston, TX; and †Department of Dermatology, University of Texas Medical Branch, Galveston, TX.

The American Journal of Dermatopathology

|October 19, 2016

Summary

Chordoma, a rare bone cancer, can rarely spread to the skin. This case highlights diagnosing rare cutaneous metastasis from sacral chordoma using dermatopathology.

More Related Videos

An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas

An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas

Published on: October 10, 2025

Orthotopic Xenografting of Human Luciferase-Tagged Malignant Peripheral Nerve Sheath Tumor Cells for in vivo Testing of Candidate Therapeutic Agents

Orthotopic Xenografting of Human Luciferase-Tagged Malignant Peripheral Nerve Sheath Tumor Cells for in vivo Testing of Candidate Therapeutic Agents

Published on: March 7, 2011

Related Experiment Videos

Last Updated: Mar 13, 2026

Surgical Transplantation of Tumor Cells into the Spinal Cord of Mice

Surgical Transplantation of Tumor Cells into the Spinal Cord of Mice

Published on: December 27, 2024

An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas

An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas

Published on: October 10, 2025

Orthotopic Xenografting of Human Luciferase-Tagged Malignant Peripheral Nerve Sheath Tumor Cells for in vivo Testing of Candidate Therapeutic Agents

Orthotopic Xenografting of Human Luciferase-Tagged Malignant Peripheral Nerve Sheath Tumor Cells for in vivo Testing of Candidate Therapeutic Agents

Published on: March 7, 2011

Area of Science:

Oncology
Dermatopathology
Skeletal System Neoplasms

Background:

Chordoma is a rare bone malignancy originating from notochordal remnants, typically presenting with slow local progression, recurrence, and metastasis.
Cutaneous metastasis from chordoma is exceptionally rare, posing diagnostic challenges due to non-specific skin findings and the tumor's infrequency.

Observation:

A 61-year-old male with a history of sacral chordoma developed a scalp nodule 8 years post-excision.
Physical examination revealed a 1 cm dome-shaped nodule on the left occipital scalp.
Histopathology showed a dermal proliferation of ovoid and physaliferous cells with characteristic cytoplasm and nuclei.

Findings:

Immunohistochemistry confirmed tumor cells positive for S-100 protein, pancytokeratin (AE1/AE3), and brachyury.
Negative staining for smooth muscle actin (SMA), P63, and CK7 supported the diagnosis.
The findings were consistent with cutaneous metastasis of sacral chordoma, termed chordoma cutis.

Implications:

This case underscores the critical role of dermatopathology in diagnosing rare presentations of chordoma.
Accurate diagnosis of cutaneous chordoma metastasis is vital for appropriate patient management and prognosis.
Recognizing this rare entity aids in differentiating it from other cutaneous neoplasms.